Evidence map›Paper›PMID 27611361›Full record

ArticleThe International journal of eating disorders2017

Assessment of sex differences in bone deficits among adolescents with anorexia nervosa.

Jason M Nagata, Neville H Golden, Rebecka Peebles, Jin Long, Mary B Leonard, Audrey O Chang, Jennifer L Carlson

Open access · greenAbstract read
In one paragraph

Article in The International journal of eating disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  6. Review
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  9. Article
  10. Anorexia Nervosa and Bone.Current opinion in endocrine and metabolic research · 2018
    Article
  11. Differential Risk Factors for Unhealthy Weight Control Behaviors by Sex and Weight Status Among U.S. Adolescents.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2018
    Article
  12. Article
  13. Article
  14. Assessment of Sex Differences in Fracture Risk Among Patients With Anorexia Nervosa: A Population-Based Cohort Study Using The Health Improvement Network.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Article
  15. Assessment of Sex Differences in Body Composition Among Adolescents With Anorexia Nervosa.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jason M NagataDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California.ORCID 0000-0002-6541-0604
Neville H GoldenDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Rebecka PeeblesDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jin LongDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Mary B LeonardDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Audrey O ChangDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Jennifer L CarlsonDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, California.
Stanford University · USChildren's Hospital of Philadelphia · US

Funding

Multi-center Randomized Controlled Trial of Refeeding in Anorexia NervosaR01HD082166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARBER, ANDREA K · 2015 to 2025
$5.7M
Weight gain and functional body composition in adolescents with anorexia nervosaK23DK100558 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PEEBLES, REBECKA · 2015 to 2019
$900k
NICHD NIH HHS R01 HD082166NIDDK NIH HHS K23 DK100558
6 · The paper itself

Abstract

objectiveThe objective of this study was to compare sex differences in bone deficits among adolescents with anorexia nervosa (AN) and to identify other correlates of bone health.

methodElectronic medical records of all patients 9-20 years of age with a DSM-5 diagnosis of AN who were evaluated by the eating disorders program at Stanford with dual-energy X-ray absorptiometry (DXA) between March 1997 and February 2011 were retrospectively reviewed. Whole body bone mineral content Z-scores and bone mineral density (BMD) Z-scores at multiple sites were recorded using the Bone Mineral Density in Childhood Study (BMDCS) reference data.

resultsA total of 25 males and 253 females with AN were included, with median age 15 years (interquartile range [IQR] 14-17) and median duration of illness 9 months (IQR 5-13). Using linear regression analyses, no significant sex differences in bone deficits were found at the lumbar spine, total hip, femoral neck, or whole body when controlling for age, %mBMI, and duration of illness. Lower %mBMI was significantly associated with bone deficits at all sites in adjusted models. DISCUSSION: This is the first study to evaluate sex differences in bone health among adolescents with AN, using novel DSM-5 criteria for AN and robust BMDCS reference data. We find no significant sex differences in bone deficits among adolescents with AN except for a higher proportion of females with femoral neck BMD Z-scores <-1. Degree of malnutrition was correlated with bone deficits at all sites. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2017; 50:352-358).

Indexed as

Sex CharacteristicsAbsorptiometry, PhotonAdolescentAnorexia NervosaBody Mass IndexBone DensityChildFemaleFemur NeckHumansLumbar VertebraeMaleYoung Adultanorexia nervosabone densitybone healthdual-energy X-ray absorptiometryDXAeating disorderssex differences

Identifiers

PMID27611361
PMCPMC6613779
OpenAlexW2519730067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.