ArticleAnesthesiology2016
Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity.
Article in Anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 29 citations in OpenAlex.
- The lung in acute respiratory failure: insights from synchrotron radiation imaging.Intensive care medicine experimental · 2026Review
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Spatial encoding and growth-related change of sheep lung radiomic features.Frontiers in veterinary science · 2025Article
- Regional pulmonary perfusion, blood volume, and their relationship change in experimental early ARDS.Scientific reports · 2024Article
- Worsening of lung perfusion to tissue density distributions during early acute lung injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: A Pilot Study.Journal of personalized medicine · 2023Article
- High-Temporal-Resolution Lung Kinetic Modeling Using Total-Body Dynamic PET with Time-Delay and Dispersion Corrections.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury.Frontiers in physiology · 2023Review
- Visceral fat inflammation and fat embolism are associated with lung's lipidic hyaline membranes in subjects with COVID-19.International journal of obesity (2005) · 2022Article
- Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions.Scientific reports · 2022Article
- Selective Lobe Ventilation and a Novel Platform for Pulmonary Drug Delivery.Journal of cardiothoracic and vascular anesthesia · 2021Review
- A Data Report on the Curation and Development of a Database of Genes for Acute Respiratory Distress Syndrome.Frontiers in genetics · 2021Article
- New Frontiers in Functional and Molecular Imaging of the Acutely Injured Lung: Pathophysiological Insights and Research Applications.Frontiers in physiology · 2021Review
- Physiological mechanism and spatial distribution of increased alveolar dead-space in early ARDS: An experimental study.Acta anaesthesiologica Scandinavica · 2021Article
- Inflammatory Activity in Atelectatic and Normally Aerated Regions During Early Acute Lung Injury.Academic radiology · 2020Article
- A Physiologically Informed Strategy to Effectively Open, Stabilize, and Protect the Acutely Injured Lung.Frontiers in physiology · 2020Review
- Spatial Heterogeneity of Lung Strain and Aeration and Regional Inflammation During Early Lung Injury Assessed with PET/CT.Academic radiology · 2019Article
- A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease.Contrast media & molecular imaging · 2019Review
- Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.American journal of respiratory and critical care medicine · 2018Article
- Unstable Inflation Causing Injury. Insight from Prone Position and Paired Computed Tomography Scans.American journal of respiratory and critical care medicine · 2018Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAcute respiratory distress syndrome (ARDS) is an inflammatory condition comprising diffuse lung edema and alveolar damage. ARDS frequently results from regional injury mechanisms. However, it is unknown whether detectable inflammation precedes lung edema and opacification and whether topographically differential gene expression consistent with heterogeneous injury occurs in early ARDS. The authors aimed to determine the temporal relationship between pulmonary metabolic activation and density in a large animal model of early ARDS and to assess gene expression in differentially activated regions.
methodsThe authors produced ARDS in sheep with intravenous lipopolysaccharide (10 ng ⋅ kg ⋅ h) and mechanical ventilation for 20 h. Using positron emission tomography, the authors assessed regional cellular metabolic activation with 2-deoxy-2-[(18)F]fluoro-D-glucose, perfusion and ventilation with NN-saline, and aeration using transmission scans. Species-specific microarray technology was used to assess regional gene expression.
resultsMetabolic activation preceded detectable increases in lung density (as required for clinical diagnosis) and correlated with subsequent histologic injury, suggesting its predictive value for severity of disease progression. Local time courses of metabolic activation varied, with highly perfused and less aerated dependent lung regions activated earlier than nondependent regions. These regions of distinct metabolic trajectories demonstrated differential gene expression for known and potential novel candidates for ARDS pathogenesis.
conclusionsHeterogeneous lung metabolic activation precedes increases in lung density in the development of ARDS due to endotoxemia and mechanical ventilation. Local differential gene expression occurs in these early stages and reveals molecular pathways relevant to ARDS biology and of potential use as treatment targets.
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