ArticleScientific reports2016
Extract of Ganoderma formosanum Mycelium as a Highly Potent Tyrosinase Inhibitor.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- tris-Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations.Chemistry & biodiversity · 2026Article
- Article
- Sustainable repeated-batch fermentation of immobilized Ganoderma formosanum for enhanced production of anti-melanogenic bioactive compounds.NPJ science of food · 2025Article
- Aromatic compounds and organic acids identified from Ganoderma formosanum exhibit synergistic anti-melanogenic effects.Journal of food and drug analysis · 2024Article
- Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model.Molecules (Basel, Switzerland) · 2023Review
- The Inhibitory Effect of Polyphenon 60 from Green Tea on Melanin and Tyrosinase in Zebrafish and A375 Human Melanoma Cells.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities.Antioxidants (Basel, Switzerland) · 2021Article
- Anti-Melanogenesis Activity of 6-Molecules (Basel, Switzerland) · 2020Article
- Melanogenic Inhibition and Toxicity Assessment of Flavokawain A and B on B16/F10 Melanoma Cells and Zebrafish (Molecules (Basel, Switzerland) · 2020Article
- Natural skin-whitening compounds for the treatment of melanogenesis (Review).Experimental and therapeutic medicine · 2020Article
- Development of Multifunctional Cosmetic Cream Using Bioactive Materials fromAntioxidants (Basel, Switzerland) · 2020Article
- Germinated Riceberry Rice Enhanced Protocatechuic Acid and Vanillic Acid to Suppress Melanogenesis through Cellular Oxidant-Related Tyrosinase Activity in B16 Cells.Antioxidants (Basel, Switzerland) · 2020Article
- The Antiproliferation Activity ofMycobiology · 2020Article
- Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish.Food science & nutrition · 2019Article
- Anti-Melanogenic Effect from Submerged Mycelial Cultures ofMycobiology · 2019Article
- A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine.Medicina (Kaunas, Lithuania) · 2018Review
- Tyrosinase-based TLC Autography for anti-melanogenic drug screening.Scientific reports · 2018Article
- Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase.Oncotarget · 2017Article
- Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies.Drug design, development and therapy · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the inhibitory effect of Ganoderma formosanum mycelium extracts on tyrosinase, the central regulatory enzyme being responsible for cutaneous pigmentation, was investigated in both cell-free and cellular enzymatic systems, as well as in phenotype-based zebrafish model. Bioassay-guided purification indicated that the ethyl acetate fraction of G. fromosanum mycelium ethanolic extract (GFE-EA) demonstrated the highest inhibition toward cell-free tyrosinase (IC50 = 118.26 ± 13.34 ppm). The secreted and intracellular melanin of B16-F10 cells were reduced by GFE-EA through suppression of tyrosinase activity (IC50 = 102.27 ± 9.49 ppm) and its protein expression. Moreover, GFE-EA decreased surface pigmentation level of zebrafish via down-regulation of tyrosinase activity. Most of all, there is no significant difference in morphology and mortality between control and GFE-EA treated groups. Not only does GFE-EA exhibit similar depigmenting efficacy to kojic acid with lower dosage (approximately one-seventh of dose), but show less toxicity to zebrafish. It is worth noting that GFE-EA is extracted from mycelium, which subverts the general concept that mycelium lacks certain bioactivities possessed by fruit bodies. Altogether, it would appear that GFE-EA has great potential for application in the cosmetics industry.
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