ReviewThe British journal of radiology2017
Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications.
Review in The British journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03473249 (Clinical Effectiveness of Contrast-Enhanced Ultrasound in the Evaluation of Blunt Abdominal Trauma in Young Children), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Effectiveness of Contrast-Enhanced Ultrasound in the Evaluation of Blunt Abdominal Trauma in Young Children
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Malignancy risk and contrast-enhanced ultrasound guidance in non-diagnostic biopsies of peripheral lung lesions: a multicenter study.European radiology · 2026Article
- Ultrasound features for pediatric testicular lesions: 20 years of ultrasound practice interpreted through the 2022 WHO Classification.Quantitative imaging in medicine and surgery · 2026Article
- Bubbles in the barely born-contrast-enhanced ultrasound in neonates: a single-center experience.European journal of pediatrics · 2026Article
- Evaluation of hepatic infantile hemangiomas: the potential of contrast-enhanced ultrasound.Frontiers in cardiovascular medicine · 2026Article
- Percutaneous Kidney Puncture Using a Novel Contrast-enhanced Ultrasound-guided Technique: First Swine ModelEuropean urology open science · 2025Article
- Performance of grayscale combined with contrast-enhanced ultrasound in differentiating benign and malignant pediatric ovarian masses.European radiology · 2025Article
- Unusual pediatric lung infections: imaging findings.Pediatric radiology · 2024Review
- The Utility of Contrast Enhanced Ultrasound and Elastography in the Early Detection of Fibro-Stenotic Ileal Strictures in Children with Crohn's Disease.Pediatric gastroenterology, hepatology & nutrition · 2023Article
- Review
- Contrast-enhanced ultrasound of blunt abdominal trauma in children.Pediatric radiology · 2021Review
- Contrast-enhanced ultrasound of pediatric lungs.Pediatric radiology · 2021Review
- Utility of contrast-enhanced ultrasound for solid mass surveillance and characterization in children with tuberous sclerosis complex: an initial experience.Pediatric nephrology (Berlin, Germany) · 2021Article
- Paediatric focal nodular hyperplasia: A case study of typical contrast-enhanced ultrasound findings with quantitative analysis and correlated with magnetic resonance imaging.Ultrasound (Leeds, England) · 2021Article
- Case Report: Report of 2 Different Cases of Ovarian Teratoma Evaluated by Dynamic Contrast-Enhanced Ultrasound.Frontiers in pediatrics · 2021Article
- Contrast-enhanced ultrasound for multiple liver lesions after bone marrow transplant in a child with leukaemia: Multifocal focal nodular hyperplasia.Ultrasound (Leeds, England) · 2019Article
- Contrast-enhanced ultrasound (CEUS) in pediatric blunt abdominal trauma.Journal of ultrasound · 2019Review
- Diagnosis of congenital and acquired focal lesions in the neck, abdomen, and pelvis with contrast-enhanced ultrasound: a pictorial essay.European journal of pediatrics · 2018Article
- Pediatric contrast-enhanced ultrasound in the United States: a survey by the Contrast-Enhanced Ultrasound Task Force of the Society for Pediatric Radiology.Pediatric radiology · 2018Article
- Contrast-enhanced ultrasound (CEUS) in abdominal intervention.Abdominal radiology (New York) · 2018Review
- Static and Dynamic Ultrasound Imaging to Visualize the Bladder, Bladder Neck, Urethra, and Pelvic Floor in Children with Daytime Incontinence.Frontiers in pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrast-enhanced ultrasound (CEUS) represents a complementary technique to greyscale and colour Doppler ultrasonography which allows for real-time visualization and characterization of tissue perfusion. Its inherent advantages in the child makes ultrasonography an ideal imaging modality; repeatability and good tolerance along with the avoidance of CT, a source of ionizing radiation, renders ultrasonography imaging desirable. Although currently paediatric CEUS is principally used in an "off-label" manner, ultrasonography contrast agents have received regulatory approval for assessment of paediatric focal liver lesions (FLL) in the USA. The safety of ultrasound contrast-agents is well documented in adults, as safe as or even surpassing the safety profile of CT and MR contrast agents. Except for the established intracavitary use of CEUS in voiding urosonography, i.v. paediatric applications have been introduced with promising results in the abdominal trauma initial diagnosis and follow-up, characterization and differential diagnosis of FLL and characterization of lung, pleura, renal and splenic pathology. CEUS has also been used to detect complications after paediatric transplantation, evaluate inflammatory bowel disease activity and assess tumour response to antiangiogenic therapy. The purpose of this review was to present these novel i.v. paediatric applications of CEUS and discuss their value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.