ArticlePloS one2016
Comparison of Human Neonatal and Adult Blood Leukocyte Subset Composition Phenotypes.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 73 citations in OpenAlex.
- Early antibiotic exposure and vaccine immune responses in preterm infants: potential sex-specific differences.Gut microbes · 2026Observational
- Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.Cell death & disease · 2026Review
- Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood.Advanced biology · 2026Article
- Increased interleukin-8 levels in cord blood serum of newborn-possible effect of cytokine dysregulation in pregnancies complicated by rheumatic disease on newborn vasculature.Frontiers in immunology · 2026Article
- Automated Red and White Blood Cell Counting in Capillary Microsamples by Sysmex-XN Predilution Mode.International journal of laboratory hematology · 2025Article
- DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation.Communications biology · 2025Article
- Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.Seminars in immunopathology · 2025Review
- Immunophenotypic and Functional Interindividual Variability in Banked Cord Blood Cells: Insights for Advanced Therapies.International journal of molecular sciences · 2025Article
- Article
- Development of a Spectral Flow Cytometry Analysis Pipeline for High-dimensional Immune Cell Characterization.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns that is distinct from adult blood cells.Clinical and experimental immunology · 2024Article
- Development of a Spectral Flow Cytometry Analysis Pipeline for High-Dimensional Immune Cell Characterization.bioRxiv : the preprint server for biology · 2024Article
- Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro.Communications biology · 2024Article
- Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function.Frontiers in immunology · 2024Article
- Role of innate T cells in necrotizing enterocolitis.Frontiers in immunology · 2024Review
- Age-dependent transcriptomic profiles of leukocytes in pediatric population.Clinical immunology (Orlando, Fla.) · 2023Article
- Normative data for paediatric lymphocyte subsets: A pilot study from western India.The Indian journal of medical research · 2023Article
- Umbilical Cord Blood-Derived Monocytes as A Reliable Source of Functional Macrophages for Biomedical Research.Cell journal · 2023Article
- Sex Differences in the Frequencies of B and T Cell Subpopulations of Human Cord Blood.International journal of molecular sciences · 2023Article
- Single-cell RNA sequencing of intestinal immune cells in neonatal necrotizing enterocolitis.Pediatric surgery international · 2023Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human peripheral leukocyte subset composition depends on genotype variation and pre-natal and post-natal environmental influence diversity. We quantified this composition in adults and neonates, and compared the median values and dispersal ranges of various subsets in them. We confirmed higher frequencies of monocytes and regulatory T cells (Tregs), similar frequencies of neutrophils, and lower frequencies of CD8 T cells, NKT cells, B1 B cells and gamma-delta T cells in neonatal umbilical cord blood. Unlike previous reports, we found higher frequencies of eosinophils and B cells, higher CD4:CD8 ratios, lower frequencies of T cells and iNKT cells, and similar frequencies of CD4 T cells and NK cells in neonates. We characterized monocyte subsets and dendritic cell (DC) subsets in far greater detail than previously reported, using recently described surface markers and gating strategies and observed that neonates had lower frequencies of patrolling monocytes and lower myeloid dendritic cell (mDC):plasmacytoid DC (pDC) ratios. Our data contribute to South Asian reference values for these parameters. We found that dispersal ranges differ between different leukocyte subsets, suggesting differential determination of variation. Further, some subsets were more dispersed in adults than in neonates suggesting influences of postnatal sources of variation, while some show the opposite pattern suggesting influences of developmental process variation. Together, these data and analyses provide interesting biological possibilities for future exploration.
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