Evidence map›Paper›PMID 27610386›Full record

ReviewBioMed research international2016

PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies.

Yiqin Zhou, James H-C Wang

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 7 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03774251 early_phase1withdrawnnot on this mapstarted 2019, after this paper: background citation

A Randomized Controlled Trial of Ultrasound-guided Platelet-Rich-Plasma (PRP) Injection Versus Extracorporeal Shock Wave Therapy (ESWT) for Great Trochanter Pain Syndrome (GTPS) With Gluteus Medius or Minimus Tendinopathy

TypeinterventionalSponsorStanford UniversityRan2019 to 2021Enrolled0ConditionsGreater Trochanter Pain Syndrome, Gluteus Medius Tendinopathy, Gluteus Minimus TendinopathyArmsPlatelet-Rich Plasma Injection, Extracorporeal Shock Wave Therapy
NCT07540806 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Ultrasound-Guided Percutaneous Needle Tenotomy (PNT) vs Percutaneous Ultrasonic Needle Tenotomy (PUT) for Gluteal Tendinosis

TypeinterventionalSponsorUniversity of Colorado, DenverRan2026 to 2028Enrolled110ConditionsTendinopathy, Tendinosis, Gluteal TendinitisArmsPercutaneous needle tenotomy (PNT), Percutaneous ultrasonic tenotomy (PUT, Tenex Device)
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 7 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Academic Influence and Industry Funding in Platelet-Rich Plasma Injections: Coauthorship Network Analysis.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Yiqin ZhouMechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 210 Lothrop Street, BST, E1640, Pittsburgh, PA 15213, USA; Joint Surgery and Sports Medicine Department, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.ORCID 0000-0001-8457-325X
James H-C WangMechanoBiology Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 210 Lothrop Street, BST, E1640, Pittsburgh, PA 15213, USA.ORCID 0000-0001-7279-0679
University of Pittsburgh · US

Funding

Repair of tendinopathic tendonsR01AR061395 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2011 to 2015
$1.8M
The role of TSCs in the degenerative tendinopathy induced by mechanical loadingR01AR065949 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2015 to 2019
$1.7M
NIAMS NIH HHS R01 AR061395NIAMS NIH HHS R01 AR065949
6 · The paper itself

Abstract

Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Both in vitro and in vivo studies describe PRP's anabolic and anti-inflammatory effects on tendons. While some clinical trials support these findings, others refute them. In this review, we discuss the effectiveness of PRP to treat tendon injuries with evidence presented in basic science studies and the potential reasons for the controversial results in clinical trials. Finally, we comment on the approaches that may be required to improve the efficacy of PRP treatment for tendinopathy.

Indexed as

Platelet-Rich PlasmaHumansInflammationTendinopathy

Identifiers

PMID27610386
PMCPMC5004020
OpenAlexW2517826770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.