Evidence map›Paper›PMID 27610385›Full record

ReviewBioMed research international2016

Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach.

Rosa Estela Quiroz-Castañeda, Itzel Amaro-Estrada, Sergio Darío Rodríguez-Camarillo

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular Detection ofPathogens (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Co-existence of MultipleFrontiers in microbiology · 2022
    Article
  6. Review
  7. Review
  8. Screening and Analysis ofFrontiers in veterinary science · 2021
    Article
  9. Article
  10. Whole-Genome Sequencing of Mexican Strains ofInternational journal of genomics · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rosa Estela Quiroz-CastañedaUnidad de Anaplasmosis, Centro Nacional en Investigación Disciplinaria en Parasitología Veterinaria, INIFAP, Carretera Federal Cuernavaca-Cuautla 8534, 62574 Jiutepec, MOR, Mexico.ORCID 0000-0002-4481-8360
Itzel Amaro-EstradaUnidad de Anaplasmosis, Centro Nacional en Investigación Disciplinaria en Parasitología Veterinaria, INIFAP, Carretera Federal Cuernavaca-Cuautla 8534, 62574 Jiutepec, MOR, Mexico.
Sergio Darío Rodríguez-CamarilloUnidad de Anaplasmosis, Centro Nacional en Investigación Disciplinaria en Parasitología Veterinaria, INIFAP, Carretera Federal Cuernavaca-Cuautla 8534, 62574 Jiutepec, MOR, Mexico.
Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to understand the genetic diversity of A. marginale, several efforts have been made around the world. This rickettsia affects a significant number of ruminants, causing bovine anaplasmosis, so the interest in its virulence and how it is transmitted have drawn interest not only from a molecular point of view but also, recently, some genomics research have been performed to elucidate genes and proteins with potential as antigens. Unfortunately, so far, we still do not have a recombinant anaplasmosis vaccine. In this review, we present a landscape of the multiple approaches carried out from the genomic perspective to generate valuable information that could be used in a holistic way to finally develop an anaplasmosis vaccine. These approaches include the analysis of the genetic diversity of A. marginale and how this affects control measures for the disease. Anaplasmosis vaccine development is also reviewed from the conventional vaccinomics to genome-base vaccinology approach based on proteomics, metabolomics, and transcriptomics analyses reported. The use of these new omics approaches will undoubtedly reveal new targets of interest in the near future, comprising information of potential antigens and the immunogenic effect of A. marginale proteins.

Indexed as

Anaplasma marginaleAnaplasmosisBacterial VaccinesCattle DiseasesAnimalsCattleGenetic VariationGenome, BacterialBacterial Vaccines

Identifiers

PMID27610385
PMCPMC5005611
OpenAlexW2513727748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.