ArticleWorld journal of clinical pediatrics2016
Skin disease and thyroid autoimmunity in atopic South Italian children.
Article in World journal of clinical pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Skin Sceneries of Thyroid Disorders and Impact of Thyroid on Different Skin Diseases: A Scoping Review Focused on Pediatric Patients.Children (Basel, Switzerland) · 2024Article
- Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review.Journal of clinical medicine · 2024Review
- Allergy and autoimmunity in children: non-mutually exclusive diseases. A narrative review.Frontiers in pediatrics · 2023Review
- Screening Guidelines for Thyroid Function in Children With Alopecia Areata.JAMA dermatology · 2017Article
- Alopecia Areata: An Update on Treatment Options for Children.Paediatric drugs · 2017Review
- Is Atopic Dermatitis a Risk Factor for Thyroid Autoimmunity? - A Cross-Sectional Study from a Tertiary Care Center in India.Indian dermatology online journalArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo verify the prevalence of thyroid autoimmunity (TA) and the possible association between atopy and TA in children affected by skin disease.
methodsThree hundred and twenty-four children consecutively referred due to skin disease symptoms to our Pediatric Department were enrolled. One hundred and eighty-seven were diagnosed with atopic dermatitis (AD), 95 with acute urticaria, 40 with chronic urticaria (CU), and 2 with alopecia areata (AA). According to the work-up for atopy, the children were divided into two groups: Atopics and non-atopics. TA was diagnosed by serum thyroid peroxidase autoantibodies and/or thyroglobulin autoantibodies levels more than twice normal values over a period of two months by immunoassay.
resultsIn all children with skin disease, a significant prevalence of TA in atopics compared with non-atopics (13.67% vs 2.67%, P = 0.0016) and a significant association between TA and atopy (OR = 5.76, 95%CI: 1.71-19.35) were observed. These findings were confirmed as significant in children with AD: TA in atopics was 11.5%, while TA in non-atopics was 2.7% (P = 0.03, OR = 4.68, 95%CI: 1.02-21.38). In addition, atopics with CU showed a significantly higher prevalence of TA (26.9%), but none of the non-atopics showed CU (P = 0.0326). On the other hand, atopics with AA showed a 100% (2 out of 2) prevalence of TA, compared with none of the non-atopics.
conclusionIn children with skin disease, atopy seems to be associated with an increased risk of TA.
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