Evidence map›Paper›PMID 27610126›Full record

ArticleInterventional neurology2016

Aneurysm Study of Pipeline in an Observational Registry (ASPIRe).

David F Kallmes, Waleed Brinjikji, Edoardo Boccardi, Elisa Ciceri, Orlando Diaz, Rabih Tawk, Henry Woo, Pascal Jabbour, Felipe Albuquerque, Rene Chapot and 25 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interventional neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 7 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 7 syntheses or guidelines pooled it, 205 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Article
  13. Early clinical experience with the new generation Pipeline Vantage flow diverter in the treatment of unruptured saccular aneurysms using short-term dual antiplatelet therapy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  14. Comparison of pipeline embolization device, flow re-direction endoluminal device and surpass flow diverters in the treatment of intracerebral aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  15. Observational
  16. Article
  17. First clinical experience with the Derivo 2heal embolization device for the treatment of intracranial aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  18. PREDICT: Precise deployment of Silk Vista Baby in confined territory: A technical note.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 9 countries.

David F KallmesDepartment of Radiology, Mayo Clinic, Rochester, Minn., USA.
Waleed BrinjikjiDepartment of Radiology, Mayo Clinic, Rochester, Minn., USA.
Edoardo BoccardiDepartment of Neuroradiology, Niguarda Ca' Granda Hospital of Milan, Milan, Italy.
Elisa CiceriDepartment of Radiology, Istituto Neurologico Carlo Besta, Milan, Italy.
Orlando DiazDepartment of Radiology, Houston Methodist Hospital, Houston, Tex., USA.
Rabih TawkDepartment of Neurosurgery, Mayo Clinic, Jacksonville, Fla., USA.
Henry WooDepartments of Neurosurgery at Stony Brook University, Stony Brook, N.Y., USA.
Pascal JabbourDepartment of Neurosurgery, Thomas Jefferson University, Philadelphia, Pa., USA.
Felipe AlbuquerqueDepartments of Neurosurgery, Phoenix, Ariz., USA.
Rene ChapotNeurointerventional Services, Department of Interventional Neuroradiology, Alfried Krupp Hospital, Essen, Germany.
Alain BonafeDepartment of Radiology, CHU Montpellier, Montpellier, France.
Shervin R DashtiDepartment of Neurosurgery, Norton Neuroscience Institute, Norton Healthcare, Louisville, Ky., USA.
Josser E Delgado AlmandozDepartment of Radiology, Neuroscience Institute, Abbott Northwestern Hospital, Minneapolis, Minn., USA.
Curtis GivenNeurointerventional Services, Baptist Health Lexington, Lexington, Ky., USA.
Michael E KellyDivision of Neurosurgery, Royal University Hospital, University of Saskatchewan, Saskatoon, Sask., Canada.
DeWitte T CrossDepartment of Radiology, Washington University School of Medicine, St. Louis, Mo., USA.
Gary DuckwilerDepartment of Neuroradiology, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USA.
Nasser RazackNeurointerventional Associates, P.A., St. Petersburg, Fla., USA.
Ciaran J PowersDepartment of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Sebastian FischerDepartment of Radiology, Klinikum Stuttgart, Stuttgart, Germany.
Demetrius LopesDepartment of Neurological Surgery, Rush University Medical Center, Chicago, Ill., USA.
Mark R HarriganDepartment of Neurosurgery, University of Alabama, Birmingham, Ala., USA.
Daniel HuddleSwedish Medical Center/RIA Neurovascular, Englewood, Colo., USA.
Raymond TurnerDepartment of Neurosurgery, Medical University of South Carolina, Charleston, S.C., USA.
Osama O ZaidatDepartment of Neurology, Medical College of Wisconsin/Froedtert Hospital, Milwaukee, Wis., USA.
Luc DefreyneDepartment of Interventional Radiology, Ghent University Hospital, Gent, Belgium.
Vitor Mendes PereiraDivision of Neuroradiology, Joint Department of Medical Imaging and Division of Neurosurgery, Department of Surgery, University Health Network and Departments of Medical Imaging and Surgery, University of Toronto, Toronto, Ont., Canada.
Saruhan CekirgeDepartment of Radiology, Koru Hospital and Bayindir Hospitals, Ankara, Turkey.
David FiorellaCerebrovascular Center, Stony Brook University Medical Center, Stony Brook, N.Y., USA.
Ricardo A HanelStroke and Cerebrovascular Surgery, Lyerly Neurosurgery/Baptist Neurological Institute, Jacksonville, Fla., USA.
Pedro LylykDepartment of Neurosurgery, Clinica La Sagrada Familia, ENERI, Buenos Aires, Argentina.
Cameron McDougallEndovascular Neurosurgery, Barrow Neurological Institute, Phoenix, Ariz., USA.
Adnan SiddiquiDepartment of Neurosurgery, University at Buffalo Neurosurgery, Buffalo, N.Y., Phoenix, Ariz., USA.
Istvan SzikoraDepartment of Neurointerventional Services, National Institute of Clinical Neurosciences, Budapest, Hungary.
Elad LevyDepartment of Neurosurgery, University at Buffalo Neurosurgery, Buffalo, N.Y., Phoenix, Ariz., USA.
Mayo Clinic in Arizona · USNeurological Surgery · USUniversity at Buffalo, State University of New York · USAbbott Northwestern Hospital · USAlfried Krupp Hospital · DEAssociates in Neurology · USAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITBaptist Medical Center Jacksonville · USBarrow Neurological Institute · USBayındır Hastanesi · TRCentral Baptist Hospital · USCentre Hospitalier Universitaire de Montpellier · FRFondazione IRCCS Istituto Neurologico Carlo Besta · ITGhent University Hospital · BEInstituto Cardiovascular de Rosario · ARKlinikum Stuttgart · DEMedical College of Wisconsin · USMedical University of South Carolina · USMethodist Hospital · USNorton Healthcare · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveFew prospective studies exist evaluating the safety and efficacy of the Pipeline Embolization Device (PED) in the treatment of intracranial aneurysms. The Aneurysm Study of Pipeline In an observational Registry (ASPIRe) study prospectively analyzed rates of complete aneurysm occlusion and neurologic adverse events following PED treatment of intracranial aneurysms. MATERIALS AND

methodsWe performed a multicenter study prospectively evaluating patients with unruptured intracranial aneurysms treated with PED. Primary outcomes included (1) spontaneous rupture of the Pipeline-treated aneurysm; (2) spontaneous nonaneurysmal intracranial hemorrhage (ICH); (3) acute ischemic stroke; (4) parent artery stenosis, and (5) permanent cranial neuropathy. Secondary endpoints were (1) treatment success and (2) morbidity and mortality at the 6-month follow-up. Vascular imaging was evaluated at an independent core laboratory.

resultsOne hundred and ninety-one patients with 207 treated aneurysms were included in this registry. The mean aneurysm size was 14.5 ± 6.9 mm, and the median imaging follow-up was 7.8 months. Twenty-four aneurysms (11.6%) were small, 162 (78.3%) were large and 21 (10.1%) were giant. The median clinical follow-up time was 6.2 months. The neurological morbidity rate was 6.8% (13/191), and the neurological mortality rate was 1.6% (3/191). The combined neurological morbidity/mortality rate was 6.8% (13/191). The most common adverse events were ischemic stroke (4.7%, 9/191) and spontaneous ICH (3.7%, 7/191). The complete occlusion rate at the last follow-up was 74.8% (77/103).

conclusionsOur prospective postmarket study confirms that PED treatment of aneurysms in a heterogeneous patient population is safe with low rates of neurological morbidity and mortality. Patients with angiographic follow-up had complete occlusion rates of 75% at 8 months.

Indexed as

Flow diverterIntracranial aneurysmNeurological morbidity and mortality

Identifiers

PMID27610126
PMCPMC4934472
OpenAlexW2405525159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.