Evidence map›Paper›PMID 27610107›Full record

ReviewFrontiers in microbiology2016

Virulence Factors of Aeromonas hydrophila: In the Wake of Reclassification.

Cody R Rasmussen-Ivey, Maria J Figueras, Donald McGarey, Mark R Liles

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 311 citations in OpenAlex.

  1. Article
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  10. Detection ofMicroorganisms · 2025
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  17. Review
  18. Article
  19. Genomic Insights into the Pathogenicity of HypervirulentPathogens (Basel, Switzerland) · 2025
    Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Cody R Rasmussen-IveyDepartment of Biological Sciences, Auburn University, Auburn, AL USA.
Maria J FiguerasDepartamento de Ciencias Médicas Básicas, Facultad de Medicina y Ciencias de la Salud, Institut d'Investigació Sanitària Pere Virgili, Universidad Rovira i Virgili, Reus Spain.
Donald McGareyDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA USA.
Mark R LilesDepartment of Biological Sciences, Auburn University, Auburn, AL USA.
Auburn University · USInstitut d'Investigació Sanitària Pere Virgili · ESKennesaw State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ubiquitous "jack-of-all-trades," Aeromonas hydrophila, is a freshwater, Gram-negative bacterial pathogen under revision in regard to its phylogenetic and functional affiliation with other aeromonads. While virulence factors are expectedly diverse across A. hydrophila strains and closely related species, our mechanistic knowledge of the vast majority of these factors is based on the molecular characterization of the strains A. hydrophila AH-3 and SSU, which were reclassified as A. piscicola AH-3 in 2009 and A. dhakensis SSU in 2013. Individually, these reclassifications raise important questions involving the applicability of previous research on A. hydrophila virulence mechanisms; however, this issue is exacerbated by a lack of genomic data on other research strains. Collectively, these changes represent a fundamental gap in the literature on A. hydrophila and confirm the necessity of biochemical, molecular, and morphological techniques in the classification of research strains that are used as a foundation for future research. This review revisits what is known about virulence in A. hydrophila and the feasibility of using comparative genomics in light of this phylogenetic revision. Conflicting data between virulence factors, secretion systems, quorum sensing, and their effect on A. hydrophila pathogenicity appears to be an artifact of inappropriate taxonomic comparisons and/or be due to the fact that these properties are strain-specific. This review audits emerging data on dominant virulence factors that are present in both A. dhakensis and A. hydrophila in order to synthesize existing data with the aim of locating where future research is needed.

Indexed as

Aeromonas hydrophilabacteriacomparative genomicspathogenesisphylogeny

Identifiers

PMID27610107
PMCPMC4997093
OpenAlexW2511208249

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.