ArticleFrontiers in microbiology2016
New Genomic Insights into "Entotheonella" Symbionts in Theonella swinhoei: Mixotrophy, Anaerobic Adaptation, Resilience, and Interaction.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 38 citations in OpenAlex.
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- Chemical richness and diversity of uncultivated 'Entotheonella' symbionts in marine sponges.Nature chemical biology · 2026Article
- Deciphering the role of NtabCrRLK47 in rhizosphere microbiome remodeling and tobacco growth promotion.Frontiers in plant science · 2026Article
- Diversity and composition of sponge-associated microbiomes from Korean sponges revealed by full-length 16S rRNA analysis.Scientific reports · 2025Article
- Out of the blue: Hyperaccumulation of molybdenum in the Indo-Pacific spongeScience advances · 2024Article
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- Lineage-specific energy and carbon metabolism of sponge symbionts and contributions to the host carbon pool.The ISME journal · 2022Article
- Mixotrophic bacteria for environmental detoxification of contaminated waste and wastewater.Applied microbiology and biotechnology · 2021Review
- Strategies for culturing active/dormant marine microbes.Marine life science & technology · 2021Review
- Characterization of a sponge microbiome using an integrative genome-centric approach.The ISME journal · 2020Article
- Symbiosis, Selection, and Novelty: Freshwater Adaptation in the Unique Sponges of Lake Baikal.Molecular biology and evolution · 2019Article
- Expressed protein profile of a Tectomicrobium and other microbial symbionts in the marine sponge Aplysina aerophoba as evidenced by metaproteomics.Scientific reports · 2018Article
- Review
- Integrated metabolism in sponge-microbe symbiosis revealed by genome-centered metatranscriptomics.The ISME journal · 2017Article
- Draft Genome Sequence of "Genome announcements · 2017Article
- Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Entotheonella" (phylum "Tectomicrobia") is a filamentous symbiont that produces almost all known bioactive compounds derived from the Lithistida sponge Theonella swinhoei. In contrast to the comprehensive knowledge of its secondary metabolism, knowledge of its lifestyle, resilience, and interaction with the sponge host and other symbionts remains rudimentary. In this study, we obtained two "Entotheonella" genomes from T. swinhoei from the South China Sea through metagenome binning, and used a RASTtk pipeline to achieve better genome annotation. The high average nucleotide index values suggested they were the same phylotypes as the two "Entotheonella" phylotypes from T. swinhoei from the Japan Sea. Genomic features related to utilization of various carbon sources, peptidase secretion, CO2 fixation, sulfate reduction, anaerobic respiration, and denitrification indicated the mixotrophic nature of "Entotheonella." The endospore-forming potential along with metal- and antibiotic resistance indicated "Entotheonella" was highly resilient to harsh conditions. The potential for endospore formation also explained the widespread distribution of "Entotheonella" to some extent. The discovery of Type II (general secretion pathway proteins and the Widespread Colonization Island) and Type VI secretion systems in "Entotheonella" suggested it could secrete extracellular hydrolases, form tight adhesion, act against phagocytes, and kill other prokaryotes. Overall, the newly discovered genomic features suggest "Entotheonella" is a highly competitive member of the symbiotic community of T. swinhoei.
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