ArticleFrontiers in physiology2016
Gene Expression Profiling Reveals Functional Specialization along the Intestinal Tract of a Carnivorous Teleostean Fish (Dicentrarchus labrax).
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Functional Feeds as Immunostimulants for Aquaculture: A Molecular Perspective.Aquaculture nutrition · 2026Review
- Intestinal Immune System Expression of Coho Salmon Challenged with Oxytetracycline:International journal of molecular sciences · 2025Article
- Characteristics and Functions of Different Intestinal Segments in Juvenile Greater Amberjack (Animals : an open access journal from MDPI · 2025Article
- Biochemical, Histological, and Transcriptomic Analyses Reveal Underlying Differences in Flesh Quality between Wild and Farmed Ricefield Eel (Foods (Basel, Switzerland) · 2024Article
- An in-depth characterisation of European seabass intestinal segments for assessing the impact of an algae-based functional diet on intestinal health.Scientific reports · 2023Article
- Morphological and Molecular Functional Evidence of the Pharyngeal Sac in the Digestive Tract of Silver Pomfret,International journal of molecular sciences · 2023Article
- Differential Modulation of the European Sea Bass Gut Microbiota by Distinct Insect Meals.Frontiers in microbiology · 2022Article
- Molecular, Cellular and Functional Analysis of TRγ Chain along the European Sea BassInternational journal of molecular sciences · 2021Article
- Medicinal Plant Leaf Extract From Sage and Lemon Verbena Promotes Intestinal Immunity and Barrier Function in Gilthead Seabream (Frontiers in immunology · 2021Article
- Diet, Immunity, and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota Modulation in Gilthead Seabream (Frontiers in immunology · 2021Article
- Article
- Effects of dietary arachidonic acid in European sea bass (Dicentrarchus labrax) distal intestine lipid classes and gut health.Fish physiology and biochemistry · 2020Article
- Protective effects of seaweed supplemented diet on antioxidant and immune responses in European seabass (Dicentrarchus labrax) subjected to bacterial infection.Scientific reports · 2019Article
- The yellowtail (Seriola quinqueradiata) genome and transcriptome atlas of the digestive tract.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Article
- The effects of protein and fiber content on gut structure and function in zebrafish (Danio rerio).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
- Co-expression Analysis of Sirtuins and Related Metabolic Biomarkers in Juveniles of Gilthead Sea Bream (Frontiers in physiology · 2018Article
- Article
- Sodium salt medium-chain fatty acids andPeerJ · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-quality sequencing reads from the intestine of European sea bass were assembled, annotated by similarity against protein reference databases and combined with nucleotide sequences from public and private databases. After redundancy filtering, 24,906 non-redundant annotated sequences encoding 15,367 different gene descriptions were obtained. These annotated sequences were used to design a custom, high-density oligo-microarray (8 × 15 K) for the transcriptomic profiling of anterior (AI), middle (MI), and posterior (PI) intestinal segments. Similar molecular signatures were found for AI and MI segments, which were combined in a single group (AI-MI) whereas the PI outstood separately, with more than 1900 differentially expressed genes with a fold-change cutoff of 2. Functional analysis revealed that molecular and cellular functions related to feed digestion and nutrient absorption and transport were over-represented in AI-MI segments. By contrast, the initiation and establishment of immune defense mechanisms became especially relevant in PI, although the microarray expression profiling validated by qPCR indicated that these functional changes are gradual from anterior to posterior intestinal segments. This functional divergence occurred in association with spatial transcriptional changes in nutrient transporters and the mucosal chemosensing system via G protein-coupled receptors. These findings contribute to identify key indicators of gut functions and to compare different fish feeding strategies and immune defense mechanisms acquired along the evolution of teleosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.