ReviewFrontiers in neural circuits2016
Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis.
Review in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Body weight and waist circumference are differentially associated with the response to L-thyroxine treatment in primary hypothyroidism.Journal of clinical & translational endocrinology · 2026Article
- The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications.Frontiers in pharmacology · 2026Review
- The Orexin System in Addiction: Neuromodulatory Interactions and Therapeutic Potential.Brain sciences · 2025Review
- Loss of M1 Acetylcholine Receptor-mediated Orexinergic Activity Contributes to Immune Dysfunction in Experimental Sepsis.Research square · 2025Article
- Goat Milk Supplementation Modulates the Mitochondrial Metabolic Flexibility and Orexin-A Levels Influencing the Inflammatory Pattern in Rats.Antioxidants (Basel, Switzerland) · 2024Article
- Analysis of thyroid function and related factors in narcolepsy patients.Scientific reports · 2023Article
- Review
- Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.International journal of molecular sciences · 2022Article
- Exploring the Role of Orexinergic Neurons in Parkinson's Disease.Neurotoxicity research · 2021Review
- Transcranial Magnetic Stimulation as a Tool to Investigate Motor Cortex Excitability in Sport.Brain sciences · 2021Review
- The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System.Journal of clinical medicine · 2020Review
- Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil.Brain research · 2020Article
- The Lateral Hypothalamus: An Uncharted Territory for Processing Peripheral Neurogenic Inflammation.Frontiers in neuroscience · 2020Review
- The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity.Frontiers in physiology · 2020Review
- Functional Changes of Orexinergic Reaction to Psychoactive Substances.Molecular neurobiology · 2018Review
- Stress Profile in Remotely Piloted Aircraft Crewmembers During 2 h Operating Mission.Frontiers in physiology · 2018Article
- Adiponectin and Orexin-A as a Potential Immunity Link Between Adipose Tissue and Central Nervous System.Frontiers in physiology · 2018Review
- Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?Frontiers in physiology · 2018Article
- Exercise Influence on Hippocampal Function: Possible Involvement of Orexin-A.Frontiers in physiology · 2017Review
- Visual-spatial training efficacy in children affected by migraine without aura: a multicenter study.Neuropsychiatric disease and treatment · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypocretin/orexin (ORX) are two hypothalamic neuropeptides discovered in 1998. Since their discovery, they have been one of the most studied neuropeptide systems because of their projecting fields innervating various brain areas. The orexinergic system is tied to sleep-wakefulness cycle, and narcolepsy is a consequence of their system hypofunction. Orexinergic system is also involved in many other autonomic functions such as feeding, thermoregulation, cardiovascular and neuroendocrine regulation. The main aim of this mini review article is to investigate the relationship between ORX and thyroid system regulation. Although knowledge about the ORX system is evolving, its putative effects on hypothalamic-pituitary-thyroid (HPT) axis still appear unclear. We analyzed some studies about ORX control of HPT axis to know better the relationship between them. The studies that were analyzed suggest Hypocretin/ORX to modulate the thyroid regulation, but the nature (excitatory or inhibitory) of this possible interaction remains actually unclear and needs to be confirmed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.