ArticleNanomedicine : nanotechnology, biology, and medicine2017
Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Chitosan-Peptide Composites for Tissue Engineering Applications: Advances in Treatment Strategies.Current protein & peptide science · 2025Review
- Hydrogels for Neural Regeneration: Exploring New Horizons.Materials (Basel, Switzerland) · 2024Review
- Nanotechnology in sexual medicine.The journal of sexual medicine · 2024Article
- Advanced hydrogels: New expectation for the repair of organic erectile dysfunction.Materials today. Bio · 2023Review
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction.Nanomedicine : nanotechnology, biology, and medicine · 2021Article
- Advances in Nanoparticle Delivery System for Erectile Dysfunction: An Updated Review.Sexual medicine · 2021Article
- Self-Assembling Hydrogel Structures for Neural Tissue Repair.ACS biomaterials science & engineering · 2021Review
- Modification of a Single Atom Affects the Physical Properties of Double Fluorinated Fmoc-Phe Derivatives.International journal of molecular sciences · 2021Article
- Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing.International journal of molecular sciences · 2020Review
- An Azobenzene-Based Single-Component Supramolecular Polymer Responsive to Multiple Stimuli in Water.Journal of the American Chemical Society · 2020Article
- Optimization of Sonic Hedgehog Delivery to the Penis from Self-Assembling Nanofiber Hydrogels to Preserve Penile Morphology after Cavernous Nerve Injury.Nanomedicine : nanotechnology, biology, and medicine · 2019Article
- Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus.Experimental neurology · 2019Article
- Penile Rehabilitation: The "Up"-date.Current sexual health reports · 2018Article
- Pelvic and hypogastric nerves are injured in a rat prostatectomy model, contributing to development of stress urinary incontinence.Scientific reports · 2018Article
- Peptide amphiphile delivery of sonic hedgehog protein promotes neurite formation in penile projecting neurons.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
- Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair.Journal of tissue engineering and regenerative medicine · 2018Article
- Amyloid-like staining property of RADA16-I nanofibers and its potential application in detecting and imaging the nanomaterial.International journal of nanomedicine · 2018Article
- A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.ACS biomaterials science & engineering · 2017Article
- Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Erectile dysfunction (ED) has high impact on quality of life in prostatectomy, diabetic and aging patients. An underlying mechanism is cavernous nerve (CN) injury, which causes ED in up to 80% of prostatectomy patients. We examine how sonic hedgehog (SHH) treatment with innovative peptide amphiphile nanofiber hydrogels (PA), promotes CN regeneration after injury. SHH and its receptors patched (PTCH1) and smoothened (SMO) are localized in PG neurons and glia. SMO undergoes anterograde transport to signal to downstream targets. With crush injury, PG neurons degenerate and undergo apoptosis. SHH protein decreases, SMO localization changes to the neuronal cell surface, and anterograde transport stops. With SHH treatment SHH is taken up at the injury site and undergoes retrograde transport to PG neurons, allowing SMO transport to occur, and neurons remain intact. SHH treatment prevents neuronal degeneration, maintains neuronal, glial and downstream target signaling, and is significant as a regenerative therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.