ReviewEndocrine connections2016
Clinical aspects of symptomatic hyponatremia.
Review in Endocrine connections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Thiazide diuretics use & risk of falls & syncope among hypertensives: A retrospective cohort study.The Indian journal of medical research · 2025Article
- Validation of ICD-10 codes used to identify the main reason for hospitalization due to hyponatremia in Sweden.PloS one · 2025Article
- Lipoprotein-X: A Case of Falsely Elevated LDL Hypercholesterolemia.JACC. Case reports · 2023Article
- Article
- Electrolyte derangements in critically ill children receiving balanced versus unbalanced crystalloid fluid resuscitation.BMC nephrology · 2022Observational
- Natraemia variations induced by acute dialysis in critically ill patients: a database study.Scientific reports · 2022Article
- Osmotic demyelination syndrome following slow correction of hyponatraemia.BMJ case reports · 2021Article
- Treatment of symptomatic hyponatremia with hypertonic saline: a real-life observational study.European journal of endocrinology · 2021Observational
- Cerebral Salt Wasting in Traumatic Brain Injury Is Associated with Increased Morbidity and Mortality.Neuropsychiatric disease and treatment · 2020Article
- Syndrome of inappropriate anti-diuretic hormone secretion in cancer patients: results of the first multicenter Italian study.Therapeutic advances in medical oncology · 2019Article
- Pressure ulcers in palliative ward patients: hyponatremia and low blood pressure as indicators of risk.Clinical interventions in aging · 2017Article
- Serum Sodium, Patient Symptoms, and Clinical Outcomes in Hospitalized Patients with COVID-19.Journal of primary care & community healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia (HN) is a common condition, with a large number of etiologies and a complicated treatment. Although chronic HN has been shown to be a predictor of poor outcome, sodium-increasing treatments in chronic stable and asymptomatic HN have not proven to increase life expectancy. For symptomatic HN, in contrast, the necessity for urgent treatment has broadly been accepted to avoid the development of fatal cerebral edema. On the other hand, a too rapid increase of serum sodium in chronic HN may result in cerebral damage due to osmotic demyelinisation. Recently, administration of hypertonic saline bolus has been recommended as first-line treatment in patients with moderate-to-severe symptomatic HN. This approach is easy to memorize and holds the potential to greatly facilitate the initial treatment of symptomatic HN. First-line treatment of chronic HN is fluid restriction and if ineffective treatment with tolvaptan or in some patients other agents should be considered. A number of recommendations and guidelines have been published on HN. In the present review, the management of patients with HN in relation to everyday clinical practice is summarized with focus on the acute management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.