Evidence map›Paper›PMID 27609361›Full record

ArticleJournal of the American Heart Association2016

Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation.

Daniele Pastori, Pasquale Pignatelli, Alessio Farcomeni, Danilo Menichelli, Cristina Nocella, Roberto Carnevale, Francesco Violi

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01882114 unknown statusnot on this map

Study of Atherosclerotic Risk Factors and Oxidative Stress in Atrial Fibrillation. Relation to Cardiovascular Events

TypeobservationalSponsorUniversity of Roma La SapienzaRan2007 to 2020Enrolled3,000ConditionsAtrial Fibrillation, Metabolic Syndrome, Oxidative Stress, Atherosclerosis
NCT02947074 naunknown statusnot on this map

Meditation Practice in Pediatric Healthcare Professionals: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorDanilo Forghieri SantaellaRan2016 to 2018Enrolled60ConditionsStress, PsychologicalArmsYoga Meditation
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
  2. Review
  3. Pathogenesis of Oxidative Stress Biomarkers in Atrial Fibrillation: A Narrative Review.The Journal of innovations in cardiac rhythm management · 2026
    Review
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  16. Selenoproteins and the senescence-associated epitranscriptome.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Daniele PastoriI Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Pasquale PignatelliI Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Alessio FarcomeniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Danilo MenichelliI Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Cristina NocellaI Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Roberto CarnevaleI Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Francesco VioliI Clinica Medica, Atherothrombosis Centre, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy francesco.violi@uniroma1.it.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExperimental studies demonstrated that glutathione peroxidase 3 (GPx3), an antioxidant enzyme that catabolizes hydrogen peroxide, protects against thrombosis. Little is known about its role in cardiovascular disease. METHODS AND

resultsA prospective cohort study was conducted in 909 atrial fibrillation patients. Serum activities of GPx3, superoxide dismutase (SOD), and catalase were measured at baseline to assess the risk of cardiovascular events during a mean follow-up of 43.4 months (3291 person-years). Serum Nox2 and urinary excretion of 11-deydro-thromboxane B2 were also measured. During follow-up 160 cardiovascular events occurred (4.9%/year). Significantly lower values of GPx3 (P<0.001) and SOD (P=0.037) were detected in patients with, compared to those without, cardiovascular events. A lower survival rate was observed in patients with GPx3 (P<0.001) and SOD (P=0.010) activities below the median, as compared to those above. In a fully adjusted Cox regression model, GPx3 was the only antioxidant enzyme predictor of cardiovascular events (hazard ratio 0.647, 95% confidence interval 0.524-0.798, P<0.001). GPx3 was inversely associated with urinary 11-dehydro-thromboxane B2 (B -0.337, P<0.001) and serum Nox2 (B: -0.423, P<0.001). GPx3 activity progressively decreased with decades of age (P<0.001), with a progressive reduction in people aged ≥70 years.

conclusionsThis study provides evidence that a low antioxidant status, as depicted by reduced levels of GPx3, increases the risk of cardiovascular events in patients with atrial fibrillation. The age-related decline of GPx3 may represent a mechanism for the enhanced cardiovascular risk in the elderly population.

Indexed as

AgedAged, 80 and overAgingAtrial FibrillationCardiovascular DiseasesCatalaseCohort StudiesFemaleFollow-Up StudiesGlutathione PeroxidaseHumansIschemic Attack, TransientMaleMiddle AgedMyocardial InfarctionMyocardial Revascularization11-dehydro-thromboxane B2CatalaseCYBB protein, humanGlutathione PeroxidaseGPX3 protein, humanNADPH Oxidase 2Superoxide DismutaseThromboxane B2atrial fibrillationcardiovascular diseasecardiovascular eventscatalaseglutathioneNoxrisk factorsuperoxide dismutasethromboxane

Identifiers

PMID27609361
PMCPMC5079030
OpenAlexW2510202369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.