ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Healthy aging does not compromise the augmentation of cardiac function during heat stress.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Evaluating low-energy cooling strategies on thermal and cardiac strain in older adults exposed to very hot and dry heat with accompanying activities of daily living.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Association of left ventricular end-diastolic volume with core temperature and heart rate during very hot and dry heat stress in older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from passive heat stress in young and older adults.Physiological reports · 2025Article
- Cardiac responses to environmental heat exposure in young and older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cardiovascular challenges of aging in a hotter environment: a narrative review.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Limited matching of the cardiac output response to the peripheral demand of heat stress and exercise.Experimental physiology · 2025Article
- Article
- Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study.Physiological reports · 2024Article
- Shifting focus: Time to look beyond the classic physiological adaptations associated with human heat acclimation.Experimental physiology · 2024Review
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- Indoor overheating: A review of vulnerabilities, causes, and strategies to prevent adverse human health outcomes during extreme heat events.Temperature (Austin, Tex.) · 2024Review
- Article
- Altered cardiac β1 responsiveness in hyperthermic older adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Heat therapy: mechanistic underpinnings and applications to cardiovascular health.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Individual Responses to Heat Stress: Implications for Hyperthermia and Physical Work Capacity.Frontiers in physiology · 2020Review
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Modelling physical resilience in ageing mice.Mechanisms of ageing and development · 2019Review
- Aging and Thermoregulatory Control: The Clinical Implications of Exercising under Heat Stress in Older Individuals.BioMed research international · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During heat stress, stroke volume is maintained in young adults despite reductions in cardiac filling pressures. This is achieved by a general augmentation of cardiac function, highlighted by a left and upward shift of the Frank-Starling relation. In contrast, healthy aged adults are unable to maintain stroke volume during heat stress. We hypothesized that this would be associated with a lack of shift in the Frank-Starling relation. Frank-Starling relations were examined in 11 aged [69 ± 4 (SD) yr, 4 men/7 women] and 12 young (26 ± 5 yr, 6 men/6 women) adults during normothermic and heat stress (1.5°C increase in core temperature) conditions. During heat stress, increases in cardiac output were attenuated in aged adults (+2.5 ± 0.3 (95% CI) vs. young: +4.5 ± 0.5 l/min, P < 0.01) because of an attenuated chronotropic response (+30 ± 4 vs. young: +42 ± 5 beats/min, P < 0.01). In contrast to our hypothesis, a leftward shift of the Frank-Starling relation maintained stroke volume during heat stress in aged adults (76 ± 8 vs. normothermic: 74 ± 8 ml, P = 0.38) despite reductions in cardiac filling pressure (6.6 ± 1.0 vs. normothermic: 8.9 ± 1.1 mmHg, P < 0.01). In a subset of participants, volume loading was used to return cardiac filling pressure during heat stress to normothermic values, which resulted in a greater stroke volume for a given cardiac filling pressure in both groups. These results demonstrate that the Frank-Starling relation shifts during heat stress in healthy young and aged adults, thereby preserving stroke volume despite reductions in cardiac filling pressures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.