SynthesisScientific reports2016
Predicting the synergy of multiple stress effects.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 229 citations in OpenAlex.
- The consequences of null model selection for predicting mortality from multiple stressors.Proceedings. Biological sciences · 2021Pooled it
- A synthesis of recorded fine-scale threats to imperiled species in the United States.iScience · 2026Article
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- Time Constraints Modulate the Effects of Predator Cues and a Metal Across Life Stages in a Damselfly.Evolutionary applications · 2025Article
- Hypothesis-Driven Research on Multiple Stressors: An Analytical Framework for Stressor Interactions.Ecology and evolution · 2025Article
- Pre-Exposure to Chemicals Increases Springtail Vulnerability to High Temperatures.Global change biology · 2025Article
- Pathogen-induced alterations in fine-scale movement behaviour predict impaired reproductive success.Proceedings. Biological sciences · 2025Article
- Impact of multiple-factors on health and infections in marine mussels (Perumytilus purpuratus) inhabiting contaminated sites in the Humboldt Current System.Scientific reports · 2025Article
- Natural and lab-derived microbiomes differentially shape stressor interaction patterns of Daphnia magna.The ISME journal · 2025Article
- Landscape degradation drives metal bioaccumulation in bats from Atlantic Forest cacao region, Brazil.Environmental science and pollution research international · 2024Article
- Sick without signs. Subclinical infections reduce local movements, alter habitat selection, and cause demographic shifts.Communications biology · 2024Article
- Predicting the Combined Effects of Multiple Stressors and Stress Adaptation inEnvironmental science & technology · 2024Article
- Can pharmaceutical pollution alter the spread of infectious disease? A case study using fluoxetine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Response of wheat aphid to insecticides is influenced by the interaction between temperature amplitudes and insecticide characteristics.Frontiers in physiology · 2023Article
- Differential manifestation of RONS and antioxidant enzymes in response to singular versus combinatorial stress in Chironomus ramosus.Stress biology · 2022Article
- Local stressors mask the effects of warming in freshwater ecosystems.Ecology letters · 2022Review
- Warmer temperatures limit the effects of antidepressant pollution on life-history traits.Proceedings. Biological sciences · 2022Article
- Refocusing multiple stressor research around the targets and scales of ecological impacts.Nature ecology & evolution · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxicants and other, non-chemical environmental stressors contribute to the global biodiversity crisis. Examples include the loss of bees and the reduction of aquatic biodiversity. Although non-compliance with regulations might be contributing, the widespread existence of these impacts suggests that for example the current approach of pesticide risk assessment fails to protect biodiversity when multiple stressors concurrently affect organisms. To quantify such multiple stress effects, we analysed all applicable aquatic studies and found that the presence of environmental stressors increases individual sensitivity to toxicants (pesticides, trace metals) by a factor of up to 100. To predict this dependence, we developed the "Stress Addition Model" (SAM). With the SAM, we assume that each individual has a general stress capacity towards all types of specific stress that should not be exhausted. Experimental stress levels are transferred into general stress levels of the SAM using the stress-related mortality as a common link. These general stress levels of independent stressors are additive, with the sum determining the total stress exerted on a population. With this approach, we provide a tool that quantitatively predicts the highly synergistic direct effects of independent stressor combinations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.