Evidence map›Paper›PMID 27608819›Full record

Trial reportStroke2016

Contralaterally Controlled Functional Electrical Stimulation Improves Hand Dexterity in Chronic Hemiparesis: A Randomized Trial.

Jayme S Knutson, Douglas D Gunzler, Richard D Wilson, John Chae

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00891319 (Contralaterally Controlled FES for Chronic Arm/Hand Hemiplegia), which is not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00891319 nacompletednot on this map

Contralaterally Controlled FES for Chronic Arm/Hand Hemiplegia: Single-Site RCT

TypeinterventionalSponsorMetroHealth Medical CenterRan2009 to 2015Enrolled80ConditionsStroke, Hemiparesis, HemiplegiaArmsElectrical stimulator
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  15. An Intuitive, Bidirectional, and Adaptive Functional Electrical Stimulation System for Hand Rehabilitation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  16. Observational
  17. Neurostimulation After Stroke.Physical medicine and rehabilitation clinics of North America · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jayme S KnutsonFrom the Department of Physical Medicine and Rehabilitation (J.S.K., R.D.W., J.C.), Department of Medicine (D.D.G.), and Department of Biomedical Engineering (J.C.), Case Western Reserve University, Cleveland, OH; Cleveland Functional Electrical Stimulation Center, OH (J.S.K., R.D.W., J.C.); and Department of Physical Medicine and Rehabilitation, MetroHealth Rehabilitation Institute of Ohio (J.S.K., R.D.W., J.C.) and the Center for Health Care Research and Policy (D.D.G.), MetroHealth Medical Center, Cleveland. jayme.knutson@case.edu.
Douglas D GunzlerFrom the Department of Physical Medicine and Rehabilitation (J.S.K., R.D.W., J.C.), Department of Medicine (D.D.G.), and Department of Biomedical Engineering (J.C.), Case Western Reserve University, Cleveland, OH; Cleveland Functional Electrical Stimulation Center, OH (J.S.K., R.D.W., J.C.); and Department of Physical Medicine and Rehabilitation, MetroHealth Rehabilitation Institute of Ohio (J.S.K., R.D.W., J.C.) and the Center for Health Care Research and Policy (D.D.G.), MetroHealth Medical Center, Cleveland.
Richard D WilsonFrom the Department of Physical Medicine and Rehabilitation (J.S.K., R.D.W., J.C.), Department of Medicine (D.D.G.), and Department of Biomedical Engineering (J.C.), Case Western Reserve University, Cleveland, OH; Cleveland Functional Electrical Stimulation Center, OH (J.S.K., R.D.W., J.C.); and Department of Physical Medicine and Rehabilitation, MetroHealth Rehabilitation Institute of Ohio (J.S.K., R.D.W., J.C.) and the Center for Health Care Research and Policy (D.D.G.), MetroHealth Medical Center, Cleveland.
John ChaeFrom the Department of Physical Medicine and Rehabilitation (J.S.K., R.D.W., J.C.), Department of Medicine (D.D.G.), and Department of Biomedical Engineering (J.C.), Case Western Reserve University, Cleveland, OH; Cleveland Functional Electrical Stimulation Center, OH (J.S.K., R.D.W., J.C.); and Department of Physical Medicine and Rehabilitation, MetroHealth Rehabilitation Institute of Ohio (J.S.K., R.D.W., J.C.) and the Center for Health Care Research and Policy (D.D.G.), MetroHealth Medical Center, Cleveland.
Case Western Reserve University · US

Funding

Contralaterally Controlled FES for Chronic Arm/Hand Hemiplegia: Single-Site RCTR01HD059814 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI KNUTSON, JAYME S. · 2009 to 2014
$2.1M
NICHD NIH HHS R01 HD059814
6 · The paper itself

Abstract

background and purposeIt is unknown whether one method of neuromuscular electrical stimulation for poststroke upper limb rehabilitation is more effective than another. Our aim was to compare the effects of contralaterally controlled functional electrical stimulation (CCFES) with cyclic neuromuscular electrical stimulation (cNMES).

methodsStroke patients with chronic (>6 months) moderate to severe upper extremity hemiparesis (n=80) were randomized to receive 10 sessions/wk of CCFES- or cNMES-assisted hand opening exercise at home plus 20 sessions of functional task practice in the laboratory for 12 weeks. The task practice for the CCFES group was stimulation assisted. The primary outcome was change in Box and Block Test (BBT) score at 6 months post treatment. Upper extremity Fugl-Meyer and Arm Motor Abilities Test were also measured.

resultsAt 6 months post treatment, the CCFES group had greater improvement on the BBT, 4.6 (95% confidence interval [CI], 2.2-7.0), than the cNMES group, 1.8 (95% CI, 0.6-3.0), between-group difference of 2.8 (95% CI, 0.1-5.5), P=0.045. No significant between-group difference was found for the upper extremity Fugl-Meyer (P=0.888) or Arm Motor Abilities Test (P=0.096). Participants who had the largest improvements on BBT were <2 years post stroke with moderate (ie, not severe) hand impairment at baseline. Among these, the 6-month post-treatment BBT gains of the CCFES group, 9.6 (95% CI, 5.6-13.6), were greater than those of the cNMES group, 4.1 (95% CI, 1.7-6.5), between-group difference of 5.5 (95% CI, 0.8-10.2), P=0.023.

conclusionsCCFES improved hand dexterity more than cNMES in chronic stroke survivors. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00891319.

Indexed as

AdultAgedBrain IschemiaElectric Stimulation TherapyExercise TherapyFemaleFunctional LateralityHandHumansIntracranial HemorrhagesMaleMiddle AgedParesisRecovery of FunctionStrokeStroke Rehabilitationelectrical stimulationparesisrehabilitationtherapeuticsupper extremity

Identifiers

PMID27608819
PMCPMC5039083
OpenAlexW2507380192

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.