Evidence map›Paper›PMID 27608727›Full record

ArticleStem cells and development2016

Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy.

Drake J Smith, Levina J Lin, Heesung Moon, Alexander T Pham, Xi Wang, Siyuan Liu, Sunjong Ji, Valerie Rezek, Saki Shimizu, Marlene Ruiz and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells and development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Patient-Derived Xenograft Models in Cervical Cancer: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. Pooled it
  3. Humanized immune system animal models and their recent applications.Animal models and experimental medicine · 2026
    Review
  4. Article
  5. Article
  6. Humanized mouse models in MDS.Cell death & disease · 2025
    Review
  7. Article
  8. Review
  9. Humanized mouse model for vaccine evaluation: an overview.Clinical and experimental vaccine research · 2024
    Review
  10. Humanized mouse models for immuno-oncology research.Nature reviews. Clinical oncology · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Methods for Studying Mouse and Human Invariant Natural Killer T Cells.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Drake J Smith1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Levina J Lin1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Heesung Moon1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Alexander T Pham1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Xi Wang1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Siyuan Liu1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Sunjong Ji1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Valerie Rezek3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California , Los Angeles, California.
Saki Shimizu5 AIDS Institute, University of California , Los Angeles, California.
Marlene Ruiz5 AIDS Institute, University of California , Los Angeles, California.
Jennifer Lam5 AIDS Institute, University of California , Los Angeles, California.
Deanna M Janzen6 School of Nursing, University of California , Los Angeles, California.
Sanaz Memarzadeh3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California , Los Angeles, California.
Donald B Kohn1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Jerome A Zack1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.
Scott G Kitchen3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California , Los Angeles, California.
Dong Sung An5 AIDS Institute, University of California , Los Angeles, California.
Lili Yang1 Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 1991 to 2018
$39.9M
Stem Cell-Engineered Invariant Natural Killer T Cells for Cancer TherapyDP2CA196335 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, LILI · 2014 to 2014
$2.3M
Genetic protection of hematopoietic stem cells for stable HIV controlR01AI100652 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AN, DONG SUNG · 2012 to 2016
$1.9M
NCI NIH HHS DP2 CA196335NCI NIH HHS P30 CA016042NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI100652
6 · The paper itself

Abstract

The humanized bone marrow-liver-thymus (BLT) mouse model harbors a nearly complete human immune system, therefore providing a powerful tool to study human immunology and immunotherapy. However, its application is greatly limited by the restricted supply of human CD34

Indexed as

Allergy and ImmunologyImmunotherapyAnimalsBone MarrowCell LineageHumansInheritance PatternsLiverMiceMice, Inbred NODMice, SCIDThymus GlandT-LymphocytesCD34HSChuman immunologyhuman immunotherapyhumanized BLT micepropagating

Identifiers

PMID27608727
PMCPMC5165681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.