ArticleMolecular plant pathology2018
Condition-dependent co-regulation of genomic clusters of virulence factors in the grapevine trunk pathogen Neofusicoccum parvum.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Meta-analysis of drought-tolerant genotypes in Oryza sativa: A network-based approach.PloS one · 2019Pooled it
- Grapevine exarcerbates the virulence ofFrontiers in plant science · 2026Article
- Advances in grape and pathogen genomics toward durable grapevine disease resistance.Journal of experimental botany · 2025Review
- Genomic Insights intoJournal of fungi (Basel, Switzerland) · 2025Article
- Biochemical characterization of wood decay and metabolization of phenolic compounds by causal fungi of grapevine trunk diseases.PloS one · 2025Article
- Physiological and developmental disturbances caused by Botryosphaeria dieback in the annual stems of grapevine.Frontiers in plant science · 2024Article
- Identification of a CJournal of fungi (Basel, Switzerland) · 2022Article
- Unveiling the Secretome of the Fungal Plant PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- Tandem Mass Tags Quantitative Proteome Identification and Function Analysis of ABC Transporters inInternational journal of molecular sciences · 2022Article
- Pathogenicity Factors of Botryosphaeriaceae Associated with Grapevine Trunk Diseases: New Developments on Their Action on Grapevine Defense Responses.Pathogens (Basel, Switzerland) · 2022Review
- Article
- Diversity ofJournal of fungi (Basel, Switzerland) · 2022Article
- Comparative Transcriptomics and Gene Knockout Reveal Virulence Factors ofFrontiers in microbiology · 2022Article
- Mixed infections of fungal trunk pathogens and induced systemic phenolic compound production in grapevines.Frontiers in fungal biology · 2022Article
- Insights of theJournal of fungi (Basel, Switzerland) · 2021Article
- Increased abundance of secreted hydrolytic enzymes and secondary metabolite gene clusters define the genomes of latent plant pathogens in the Botryosphaeriaceae.BMC genomics · 2021Article
- Comparative Study of Secreted Proteins, Enzymatic Activities of Wood Degradation and Stilbene Metabolization in Grapevine Botryosphaeria Dieback Fungi.Journal of fungi (Basel, Switzerland) · 2021Article
- Article
- Phylogenomics of Plant-AssociatedFrontiers in microbiology · 2021Article
- Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir.BMC microbiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ascomycete Neofusicoccum parvum, one of the causal agents of Botryosphaeria dieback, is a destructive wood-infecting fungus and a serious threat to grape production worldwide. The capability to colonize woody tissue, combined with the secretion of phytotoxic compounds, is thought to underlie its pathogenicity and virulence. Here, we describe the repertoire of virulence factors and their transcriptional dynamics as the fungus feeds on different substrates and colonizes the woody stem. We assembled and annotated a highly contiguous genome using single-molecule real-time DNA sequencing. Transcriptome profiling by RNA sequencing determined the genome-wide patterns of expression of virulence factors both in vitro (potato dextrose agar or medium amended with grape wood as substrate) and in planta. Pairwise statistical testing of differential expression, followed by co-expression network analysis, revealed that physically clustered genes coding for putative virulence functions were induced depending on the substrate or stage of plant infection. Co-expressed gene clusters were significantly enriched not only in genes associated with secondary metabolism, but also in those associated with cell wall degradation, suggesting that dynamic co-regulation of transcriptional networks contributes to multiple aspects of N. parvum virulence. In most of the co-expressed clusters, all genes shared at least a common motif in their promoter region, indicative of co-regulation by the same transcription factor. Co-expression analysis also identified chromatin regulators with correlated expression with inducible clusters of virulence factors, suggesting a complex, multi-layered regulation of the virulence repertoire of N. parvum.
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