ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2016
Post Hybrid Cochlear Implant Hearing Loss and Endolymphatic Hydrops.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Suitable Electrode Choice for Robotic-Assisted Cochlear Implant Surgery: A Systematic Literature Review of Manual Electrode Insertion Adverse Events.Frontiers in surgery · 2022Pooled it
- Imaging meets function: radiological and vestibular predictors of long-term cochlear implant outcomes in patients with Ménière disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Development of zwitterionic hydrogel thin film coatings of cochlear implant electrode arrays that reduce intracochlear inflammation and electrode impedance.Hearing research · 2026Article
- Towards a consensus on hearing and structure preservation in cochlear implantation surgery: results of the HEARRING international group survey.Frontiers in surgery · 2026Article
- Interaural correlation of acoustic hearing preservation following sequential cochlear implantation.Frontiers in neurology · 2025Article
- Acute histological reactions in the otolith organs to inner ear drug delivery through a cochlear implant.Frontiers in neurology · 2024Article
- Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings.Acta biomaterialia · 2023Article
- Article
- Archival Human Temporal Bone: Anatomical and Histopathological Studies of Cochlear Implantation.Journal of personalized medicine · 2023Review
- Anatomical Variations of the Human Cochlea Using an Image Analysis Tool.Journal of clinical medicine · 2023Article
- Vestibular function after simultaneous bilateral cochlear implantation in adults.Frontiers in neurology · 2023Article
- Minimally Traumatic Cochlear Implant Surgery: Expert Opinion in 2010 and 2020.Journal of personalized medicine · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Pathological significance and classification of endolymphatic hydrops in otological disorders.Nagoya journal of medical science · 2022Review
- Conversations in Cochlear Implantation: The Inner Ear Therapy of Today.Biomolecules · 2022Review
- Systematic Literature Review of Hearing Preservation Rates in Cochlear Implantation Associated With Medium- and Longer-Length Flexible Lateral Wall Electrode Arrays.Frontiers in surgery · 2022Review
- Histopathologic Analysis of Temporal Bones With Otosclerosis Following Cochlear Implantation.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021Article
- Cisplatin ototoxicity histopathology.Laryngoscope investigative otolaryngology · 2021Article
- Traumatic Cochlear Implant Electrode Extrusion: Considerations, Management, and Outcome.Case reports in otolaryngology · 2021Article
- Alteration of Vestibular Function in Pediatric Cochlear Implant Recipients.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate for potential causes of delayed loss of residual hearing that variably occurs with hybrid cochlear implants. STUDY
designHistopathological evaluation of 29 human temporal bone (HTB) with cochlear implant (CI).
settingThe Neurotology and House HTB Laboratory of UCLA (House-UCLA). SUBJECTS AND
methodsHTB from CI patients from the House-UCLA HTB Laboratory (n = 28) and one courtesy of Massachusetts Eye and Ear Infirmary (MEEI). Histopathological analysis to identify the location of cochleostomy, fibrosis, and bone formation in the scala vestibuli and tympani, and endolymphatic hydrops. Spiral ganglion neuron counts were obtained. Statistical analysis compared presence of cochleostomy and location with the histopathological findings.
resultsSeventeen of 29 bones with fibrosis in the scala vestibule (SV) and tympani had evidence of a cochleostomy involving the SV containing the ductus reunions, all of which had hydrops. Ten of 11 bones had no SV fibrosis, and a cochleostomy limited to the scala tympani, of which all had no hydrops. One HTB had moderate SV fibrosis not involving the ductus reuniens, and was without hydrops. One HTB had a SV cochleostomy but the electrode ruptured Reissner's membrane, and was without hydrops. Cochleostomy was significantly associated with SV fibrosis and hydrops (p < 0.01), those without hydrops had no SV atrophy (p < 0.01). Round window insertion was associated with no fibrosis and no hydrops.
conclusionWe hypothesize that cochleostomies involving scala vestibuli incite fibrosis, compromising the ductus reuniens, causing hydrops which may cause the delayed loss of residual low frequency hearing in CI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.