Evidence map›Paper›PMID 27608289›Full record

ArticleImmunology2017

Cell-type-specific modulation of innate immune signalling by vitamin D in human mononuclear phagocytes.

Rhiannon Kundu, Aikaterini Theodoraki, Carolin T Haas, Yanjing Zhang, Benjamin Chain, Janos Kriston-Vizi, Mahdad Noursadeghi, Bernard Khoo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. 1,25(OH)International journal of molecular sciences · 2023
    Article
  5. Article
  6. Vitamin DInternational journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. [Pathogenesis of steroid-resistant asthma and the influence of vitamin D].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Dietary vitamin DNutrition & metabolism · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rhiannon KunduDivision of Infection and Immunity, University College London, London, UK.
Aikaterini TheodorakiEndocrinology, Division of Medicine, University College London, London, UK.
Carolin T HaasDivision of Infection and Immunity, University College London, London, UK.
Yanjing ZhangDivision of Infection and Immunity, University College London, London, UK.
Benjamin ChainDivision of Infection and Immunity, University College London, London, UK.
Janos Kriston-ViziMRC Laboratory for Molecular Cell Biology, University College London, London, UK.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, UK.
Bernard KhooEndocrinology, Division of Medicine, University College London, London, UK.
University College London · GBMRC Laboratory for Molecular Cell Biology · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation as a potential immunoregulatory mechanism. It is not known whether vitamin D has global or gene-specific effects on transcriptional responses downstream of innate immune stimulation, or whether vitamin D inhibition of innate immune signalling is common to different cells. We confirmed vitamin D inhibition of nuclear factor-κB (NF-κB) and p38 mitogen-activated protein kinase (MAPK) signalling in monocyte-derived DC (MDDC) stimulated with lipopolysaccharide (LPS). This was associated with global but modest attenuation of LPS-induced transcriptional changes at genome-wide level. Surprisingly, vitamin D did not inhibit innate immune NF-κB activation in monocyte-derived macrophages. Consistent with our findings in MDDC, ex vivo vitamin D treatment of primary peripheral blood myeloid DC also led to significant inhibition of LPS-inducible NF-κB activation. Unexpectedly, in the same samples, vitamin D enhanced activation of both NF-κB and MAPK signalling in primary peripheral blood monocytes. In a cross-sectional clinical cohort, we found no relationship between peripheral blood vitamin D levels and LPS-inducible activation of NF-κB and MAPK pathways in monocytes of myeloid DC. Remarkably, however, in vivo supplementation of people with vitamin D deficiency in this clinical cohort also enhanced LPS-inducible MAPK signalling in peripheral blood monocytes. Therefore, we report that vitamin D differentially modulates the molecular response to innate immune stimulation in monocytes, macrophages and dendritic cells. These results are of importance in the design of studies on vitamin D supplementation in infectious and immunological diseases.

Indexed as

Organ SpecificityAdolescentAdultAgedAged, 80 and overCells, CulturedCohort StudiesDendritic CellsHumansImmunity, InnateLipopolysaccharidesMacrophagesMiddle AgedMonocytesNF-kappa Bp38 Mitogen-Activated Protein KinasesLipopolysaccharidesNF-kappa Bp38 Mitogen-Activated Protein KinasesVitamin Ddendritic cellsmacrophagesmitogen-activated protein kinasemonocytesnuclear factor-κBvitamin D

Identifiers

PMID27608289
PMCPMC5167305
OpenAlexW2514061336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.