Evidence map›Paper›PMID 27608009›Full record

ReviewInternational journal of molecular sciences2016

Current Status of Long Non-Coding RNAs in Human Breast Cancer.

Stefanie Cerk, Daniela Schwarzenbacher, Jan Basri Adiprasito, Michael Stotz, Georg C Hutterer, Armin Gerger, Hui Ling, George Adrian Calin, Martin Pichler

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefanie CerkDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria. stefanie.cerk@medunigraz.at.
Daniela SchwarzenbacherDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria. daniela.schwarzenbacher@medunigraz.at.
Jan Basri AdiprasitoDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria. jan.adiprasito@stud.medunigraz.at.
Michael StotzDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria. michael.stotz@medunigraz.at.
Georg C HuttererDepartment of Urology, Medical University of Graz, Graz 8036, Austria. georg.hutterer@medunigraz.at.
Armin GergerDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria. armin.gerger@medunigraz.at.
Hui LingDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. hling@mdanderson.org.
George Adrian CalinDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. gcalin@mdanderson.org.
Martin PichlerDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria. martin.pichler@medunigraz.at.

Funding

Protein-coding and non-coding RNA biomarkers for early detection of CLLR01CA182905 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABRUZZO, LYNNE V., CALIN, GEORGE A. · 2014 to 2018
$2.9M
NCI NIH HHS R01 CA182905
6 · The paper itself

Abstract

Breast cancer represents a major health burden in Europe and North America, as recently published data report breast cancer as the second leading cause of cancer related death in women worldwide. Breast cancer is regarded as a highly heterogeneous disease in terms of clinical course and biological behavior and can be divided into several molecular subtypes, with different prognosis and treatment responses. The discovery of numerous non-coding RNAs has dramatically changed our understanding of cell biology, especially the pathophysiology of cancer. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts >200 nucleotides in length. Several studies have demonstrated their role as key regulators of gene expression, cell biology and carcinogenesis. Deregulated expression levels of lncRNAs have been observed in various types of cancers including breast cancer. lncRNAs are involved in cancer initiation, progression, and metastases. In this review, we summarize the recent literature to highlight the current status of this class of long non-coding lncRNAs in breast cancer.

Indexed as

Biomarkers, TumorBreast NeoplasmsCarcinomaFemaleGene Expression Regulation, NeoplasticHumansRNA, Long NoncodingBiomarkers, TumorRNA, Long Noncodingbreast cancer—carcinomalong non-coding RNAoncogenetumor suppressor

Identifiers

PMID27608009
PMCPMC5037763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.