Evidence map›Paper›PMID 27608004›Full record

ReviewMolecules (Basel, Switzerland)2016

Synthesis Approaches to (-)-Cytoxazone, a Novel Cytokine Modulator, and Related Structures.

Izabel L Miranda, Ítala K B Lopes, Marisa A N Diaz, Gaspar Diaz

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 18 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Izabel L MirandaDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil. izabelmirandaqui@gmail.com.
Ítala K B LopesDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil. italakariny@hotmail.com.
Marisa A N DiazDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa 36570-000, Brazil. marisanogueira@ufv.br.
Gaspar DiazDepartamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil. gaspardm@qui.ufmg.br.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Viçosa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(-)-Cytoxazone, originally isolated from cultures of a Streptomyces species has an oxazolidin-2-one 4,5-disubstituted ring. It is known that this natural product presents a cytokine modulator effect through the signaling pathway of Th2 cells (type 2 cytokines), which are involved in the process of growth and differentiation of cells. From this, the interest in the development of research aimed at the total synthesis of this molecule and its analogs has remained high, which can be confirmed by the large number of publications on the topic, more than 30 to date. This review focuses on the various creative methods for the synthesis of (-)-cytoxazone and its congeners. The assessment of the preparation of this oxazolidinone and related structures serves as a treatise on the efforts made in the synthesis of this important class of compound from its first total synthesis in 1999.

Indexed as

OxazolesAnimalsCytokinesHumansSignal TransductionTh2 CellsCytokinescytoxazoneOxazolesantimicrobial activitiesbiological activitycytokine modulator(−)-cytoxazoneorganic synthesisstereoselective synthesis

Identifiers

PMID27608004
PMCPMC6274428
OpenAlexW2515806149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.