ArticleObstetrics and gynecology2016
Ovarian Conservation and Overall Survival in Young Women With Early-Stage Low-Grade Endometrial Cancer.
Article in Obstetrics and gynecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Current status and targeted therapies in endometrial cancer: Molecular classification-driven treatment strategies (Review).Oncology letters · 2026Review
- Beyond Barriers: Achieving True Equity in Cancer Care.Current oncology (Toronto, Ont.) · 2025Review
- A novel marker in the ovarian preservation approach to endometrial cancer: systemic immune inflammatory index.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Screening of prognostic factors and survival analysis based on histological type for perimenopausal endometrial carcinoma treated with hysterectomy.Discover oncology · 2024Article
- Endometrial cancer of both uterine horns in a premenopausal patient with uterine didelphys: Surgical approach and considerations for adjuvant treatment.Gynecologic oncology reports · 2024Article
- Review
- Validating the 2023 FIGO staging system: A nomogram for endometrioid endometrial cancer and adenocarcinoma.Cancer medicine · 2024Article
- Article
- Nomogram Based on Immune-Inflammatory Score and Classical Clinicopathological Parameters for Predicting the Recurrence of Endometrial Carcinoma: A Large, Multi-Center Retrospective Study.Journal of inflammation research · 2024Article
- An Overview of Endometrial Cancer with Novel Therapeutic Strategies.Current oncology (Toronto, Ont.) · 2023Review
- Fertility preservation in gynecologic cancer patients.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Machine Learning and AI in Cancer Prognosis, Prediction, and Treatment Selection: A Critical Approach.Journal of multidisciplinary healthcare · 2023Review
- Developing a validated nomogram for predicting ovarian metastasis in endometrial cancer patients: a retrospective research.Archives of gynecology and obstetrics · 2022Observational
- Risk Factors and Prognosis of Early Recurrence in Stage I-II Endometrial Cancer: A Large-Scale, Multi-Center, and Retrospective Study.Frontiers in medicine · 2022Article
- Predictive Value of Serum Cytokeratin 19 Level for the Feasibility of Conserving Ovaries in Endometrial Cancer.Frontiers in medicine · 2021Article
- MRI-Based Radiomics Nomogram for Selecting Ovarian Preservation Treatment in Patients With Early-Stage Endometrial Cancer.Frontiers in oncology · 2021Article
- Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.Obstetrics and gynecology · 2020Review
- Incidence of pelvic lymph node metastasis using modern FIGO staging and sentinel lymph node mapping with ultrastaging in surgically staged patients with endometrioid and serous endometrial carcinoma.Gynecologic oncology · 2020Article
- Endometrial carcinoma in a gravid uterus: a case report and literature review.BMC pregnancy and childbirth · 2019Review
- Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer.Gynecologic oncology · 2019Article
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7 authors.
Funding
Abstract
objectiveTo characterize contributing factors for ovarian conservation during surgical treatment for endometrial cancer and to examine the association of ovarian conservation on survival of young women with early-stage, low-grade tumors.
methodsThis was a population-based study using the Surveillance, Epidemiology, and End Results program to identify surgically treated stage I type I (grade 1-2 endometrioid histology) endometrial cancer cases diagnosed between 1983 and 2012 (N=86,005). Multivariable models were used to identify independent factors for ovarian conservation. Survival outcomes and cause of death were examined for women aged younger than 50 with stage I type I endometrial cancer who underwent ovarian conservation (1,242 among 12,860 women [9.7%]).
resultsOn multivariable analysis, age younger than 50 years, grade 1 endometrioid histology, and tumor size 2.0 cm or less were noted to be independent factors for ovarian conservation (all, P<.001). For 9,110 women aged younger than 50 years with stage I grade 1 tumors, cause-specific survival was similar between ovarian conservation and oophorectomy cases (20-year rates 98.9% compared with 97.7%, P=.31), whereas overall survival was significantly higher in ovarian conservation cases than oophorectomy cases (88.8% compared with 82.0%, P=.011). On multivariable analysis, ovarian conservation remained an independent prognostic factor for improved overall survival (adjusted hazard ratio 0.73, 95% confidence interval [CI] 0.54-0.98, P=.036) and was independently associated with a lower cumulative risk of death resulting from cardiovascular disease compared with oophorectomy (20-year rates, 2.3% compared with 3.7%, adjusted hazard ratio 0.40, 95% CI 0.17-0.91, P=.029). Contrary, cause-specific survival (20-year rates 94.6% compared with 96.1%, P=.68) and overall survival (81.0% compared with 80.6%, P=.91) were similar between ovarian conservation and oophorectomy among 3,750 women aged younger than 50 years with stage I grade 2 tumors.
conclusionOvarian conservation is performed in less than 10% of young women with stage I type I endometrial cancer. Ovarian conservation is associated with decreased mortality in young women with stage I grade 1 tumors.
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