Evidence map›Paper›PMID 27607763›Full record

ArticleJournal of diabetes investigation2017

Sudoscan is an effective screening method for asymptomatic diabetic neuropathy in Chinese type 2 diabetes mellitus patients.

Fei Mao, Siying Liu, Xiaona Qiao, Hangping Zheng, Qian Xiong, Jie Wen, Lianyong Liu, Mingming Tang, Shuo Zhang, Zhaoyun Zhang and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03347669 (A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03347669 naunknown statusnot on this map

A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2017 to 2018Enrolled100ConditionsFibromyalgiaArmsSudoscan®
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Electrochemical skin conductance: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. SudoscanJournal of diabetes and metabolic disorders · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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  17. Article
  18. Review
  19. Review
  20. Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019 · on this map
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Fei MaoDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Siying LiuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Xiaona QiaoDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Hangping ZhengDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Qian XiongDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Jie WenDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Lianyong LiuDepartment of Endocrinology and Metabolism, Punan Hospital, Shanghai, China.
Mingming TangDepartment of Endocrinology and Metabolism, Jiading District Center Hospital of Shanghai, Shanghai, China.
Shuo ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Zhaoyun ZhangDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Hongying YeDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Bin LuDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Yiming LiDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CNHuashan Hospital · CNJiading District Central Hospital · CNPunan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionThe aim of the present study was to use the sudomotor function test, Sudoscan, as a screening method for the evaluation of asymptomatic diabetic distal symmetric polyneuropathy in Chinese type 2 diabetes patients. As a result, more attention could be paid to those asymptomatic patients who could be easily neglected and underdiagnosed in everyday clinic. MATERIALS AND

methodsA total of 394 Chinese type 2 diabetes patients were enrolled and tested for symptoms and clinical signs of neuropathy using the Neurological Symptom Score, Neuropathy Disability Score, and vibration perception threshold. Sudoscan was carried out, and the results were collected as the measurement of the electrochemical skin conductance of both hands and feet.

resultsIn the present study, we found that the abnormal rate of Sudoscan results in patients with asymptomatic neuropathy was higher than those without neuropathy and those with symptomatic neuropathy. This study also showed that lower electrochemical skin conductance at the feet was significantly associated with increasing symptoms, Neurological Symptom Score (r = -0.124, P < 0.05), Neuropathy Disability Score (r = -0.3, P < 0.01) and vibration perception threshold value (r = -0.18, P < 0.05). Logistic analysis showed that age (odds ratio 1.042, 95% confidence interval 1.014-1.071, P < 0.05) and feet electrochemical skin conductance levels (odds ratio 0.98, 95% confidence interval 0.962-0.993, P < 0.01) were independently associated with diabetic distal symmetric polyneuropathy.

conclusionsSudoscan might be a promising tool to screen asymptomatic diabetic distal symmetric polyneuropathy in Chinese patients with type 2 diabetes mellitus.

Indexed as

Asian PeopleChinaDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleGalvanic Skin ResponseHumansMaleMiddle AgedSensory ThresholdsTouch PerceptionDistal symmetric polyneuropathyScreeningSudoscan

Identifiers

PMID27607763
PMCPMC5415453
OpenAlexW2509862696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.