Evidence map›Paper›PMID 27607593›Full record

ReviewCurrent opinion in HIV and AIDS2017

HIV-associated malignancies in sub-Saharan Africa: progress, challenges, and opportunities.

Lameck Chinula, Agnes Moses, Satish Gopal

Abstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Evaluating the Knowledge Change Before and After Continuing Cancer Education in Malawian Nurses.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023
    Article
  10. Article
  11. Article
  12. Malignancy and viral infections in Sub-Saharan Africa: A review.Frontiers in virology (Lausanne, Switzerland) · 2023
    Article
  13. Article
  14. Article
  15. AMC-070: Lenalidomide Is Safe and Effective in HIV-Associated Kaposi Sarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  16. Review
  17. Observational
  18. Article
  19. HIV-Associated Cancer Biomarkers: A Requirement for Early Diagnosis.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lameck ChinulaaUNC Project-Malawi, Lilongwe, Malawi bUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA cUniversity of Malawi College of Medicine, Blantyre, Malawi.
Agnes Moses
Satish Gopal

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 2006 to 2014
$54.7M
SUPPORTING THE SCALE-UP HIGH QUALITY HIV CARE AND TREATMENT PROGRAMS IN MALAWI U2GPS001965 · PS · UNIVERSITY OF MALAWI · PI KAMIZA, DR. STEVE · 2009 to 2014
$12.9M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Project 3U54CA190152 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, GOPAL, SATISH · 2014 to 2019
$4.2M
Developing a clinical cohort of histopathologically characterized lymphomaK01TW009488 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2012 to 2016
$701k
Planning for a National Non-Communicable Disease Center of Research ExcellenceP20CA210285 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2016 to 2017
$517k
Molecular profiling of HIV-associated lymphoma in the US and MalawiR21CA180815 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2013 to 2014
$341k
FIC NIH HHS K01 TW009488FIC NIH HHS R25 TW009340NCHHSTP CDC HHS U2G PS001965NCI NIH HHS P20 CA210285NCI NIH HHS P30 CA016086NCI NIH HHS R21 CA180815NCI NIH HHS U01 CA121947NCI NIH HHS U54 CA190152NCI NIH HHS UM1 CA121947
6 · The paper itself

Abstract

purpose of reviewTo summarize recent developments for HIV-associated malignancies (HIVAM) in low-income and middle-income countries (LMIC) with particular focus on sub-Saharan Africa (SSA). RECENT

findingsAntiretroviral therapy (ART) scale-up is leading to epidemiologic transitions in LMIC similar to high-income countries, with aging and growth of HIV-infected populations, declining infectious deaths, increasing cancer deaths, and transitions from AIDS-defining cancers to non-AIDS defining cancers. Despite ART scale-up, the HIVAM burden remains high including an enormous AIDS-defining cancers burden in SSA. For Kaposi sarcoma, patients treated with ART and chemotherapy can experience good outcomes even in rural SSA, but Kaposi sarcoma heterogeneity remains insufficiently understood including virologic, immunologic, and inflammatory features that may be unique to LMIC. For cervical cancer, scale-up of prevention efforts including vaccination and screening is underway, with benefits already apparent despite continuing high disease burden. For non-Hodgkin lymphoma, curative treatment is possible in the ART era even in SSA, and multifaceted approaches can improve outcomes further. For many other prevalent HIVAM, care and research efforts are being established to guide treatment and prevention specifically in LMIC. SUMMARY: Sustained investment for HIVAM in LMIC can help catalyze a cancer care and research agenda that benefits HIV-positive and HIV-negative patients worldwide.

Indexed as

Africa South of the SaharaHIV InfectionsHumansNeoplasmsTreatment Outcome

Identifiers

PMID27607593
PMCPMC5241291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.