ArticleAnnals of the American Thoracic Society2016
Mediastinal and Disseminated Mycobacterium kansasii Disease in GATA2 Deficiency.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Expedited diagnosis of disseminatedASM case reports · 2025Article
- DisseminatedOpen forum infectious diseases · 2022Article
- Multiple Simultaneous Infections With Nontuberculous Mycobacteria in the Setting ofOpen forum infectious diseases · 2022Article
- Inherited GATA2 Deficiency Is Dominant by Haploinsufficiency and Displays Incomplete Clinical Penetrance.Journal of clinical immunology · 2021Article
- Pulmonary non-tuberculous mycobacterial infections: current state and future management.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Review
- Case Report: DisseminatedThe American journal of tropical medicine and hygiene · 2019Article
- Hematopoietic Stem Cell Transplantation in Primary Immunodeficiencies Beyond Severe Combined Immunodeficiency.Journal of the Pediatric Infectious Diseases Society · 2018Review
- Germline GATA2 Mutation and Bone Marrow Failure.Hematology/oncology clinics of North America · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleMycobacterium kansasii usually causes chronic pulmonary infections in immunocompetent patients. In contrast, disseminated M. kansasii disease is commonly associated with advanced human immunodeficiency virus infection, but is reported infrequently in other immunocompromised patients.
objectivesTo identify common clinical manifestations and potential risk factors for M. kansasii infection in patients with GATA2 deficiency.
methodsWe reviewed M. kansasii disease associated with GATA2 deficiency at one institution and disease associated with primary and other immunodeficiencies reported in the literature. MEASUREMENTS AND MAIN
resultsNine patients with GATA2 deficiency developed M. kansasii infections. Six patients developed disseminated disease. All patients presented with significant mediastinal lymphadenopathy or abscesses. Seven patients had pulmonary risk factors, including six smokers. The majority of patients had low numbers of neutrophils, monocytes, B cells, CD4
conclusionsDisseminated M. kansasii disease involving mediastinal lymph nodes is surprisingly common in GATA2 deficiency, but also occurs in defects of IFN-γ synthesis and response. Disseminated M. kansasii should be considered a marker indicating a need to evaluate for immunodeficiency syndromes.
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Registered trials
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