ArticlePLoS pathogens2016
Rice Dwarf Virus P2 Protein Hijacks Auxin Signaling by Directly Targeting the Rice OsIAA10 Protein, Enhancing Viral Infection and Disease Development.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 175 citations in OpenAlex.
- E3 ubiquitin ligases in plant defense: mechanisms and prospects for resistance breeding.Science China. Life sciences · 2026Review
- The Ubiquitin-Proteasome System Plays Dual Roles in Plant Antiviral Defense and Viral Pathogenicity.Plants (Basel, Switzerland) · 2026Review
- The multidimensional significance of virus-host protein interactions and their implications in the antiviral defense of plants.Stress biology · 2026Review
- A viral protein disrupts rice cell wall integrity and modulates interactions with viruses and insects.Stress biology · 2026Article
- Auxin dysregulation: a key early event in sugarcane susceptibility to Sporisorium scitamineum.BMC plant biology · 2026Article
- Review
- A plant NLR receptor activates auxin signaling through Aux/IAAs-ARF19 and YUC8-TIR1/AFBs to promote callose-mediated antiviral defense.Science advances · 2025Article
- Tomato Chlorotic Virus Minor Coat Protein Interferes With the Host Proteasome Function by Competitive Disruption of SlPAD1-SlPA4 Interaction to Enhance Viral Infection.Molecular plant pathology · 2025Article
- The microRNA OsmiR393 regulates rice brown planthopper resistance by modulating the auxin-ROS signaling cross-talk.Science advances · 2025Article
- Article
- Epidemiological studies on the incidence of papaya ringspot disease under Indian sub-continent conditions.Scientific reports · 2025Article
- Puccinia striiformis Effector PNPi Suppresses TaIAA14 Expression to Inhibit Host Cell Death Response.Molecular plant pathology · 2025Article
- Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024Review
- OsIAA23 Promotes Heading by Directly Downregulating Ghd7 in rice.Rice (New York, N.Y.) · 2024Article
- ZmGDIα-hel counters the RBSDV-induced reduction of active gibberellins to alleviate maize rough dwarf virus disease.Nature communications · 2024Article
- Different viral effectors hijack TCP17, a key transcription factor for host Auxin synthesis, to promote viral infection.PLoS pathogens · 2024Article
- OsNAC121 regulates root development, tillering, panicle morphology, and grain filling in rice plant.Plant molecular biology · 2024Article
- Integrated ATAC-seq and RNA-seq data analysis identifies transcription factors related to rice stripe virus infection in Oryza sativa.Molecular plant pathology · 2024Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- Transcriptome analysis of axillary buds in low phosphorus stress and functional analysis of TaWRKY74s in wheat.BMC plant biology · 2024Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phytohormone auxin plays critical roles in regulating myriads of plant growth and developmental processes. Microbe infection can disturb auxin signaling resulting in defects in these processes, but the underlying mechanisms are poorly understood. Auxin signaling begins with perception of auxin by a transient co-receptor complex consisting of an F-box transport inhibitor response 1/auxin signaling F-box (TIR1/AFB) protein and an auxin/indole-3-acetic acid (Aux/IAA) protein. Auxin binding to the co-receptor triggers ubiquitination and 26S proteasome degradation of the Aux/IAA proteins, leading to subsequent events, including expression of auxin-responsive genes. Here we report that Rice dwarf virus (RDV), a devastating pathogen of rice, causes disease symptoms including dwarfing, increased tiller number and short crown roots in infected rice as a result of reduced sensitivity to auxin signaling. The RDV capsid protein P2 binds OsIAA10, blocking the interaction between OsIAA10 and OsTIR1 and inhibiting 26S proteasome-mediated OsIAA10 degradation. Transgenic rice plants overexpressing wild-type or a dominant-negative (degradation-resistant) mutant of OsIAA10 phenocopy RDV symptoms are more susceptible to RDV infection; however, knockdown of OsIAA10 enhances the resistance of rice to RDV infection. Our findings reveal a previously unknown mechanism of viral protein reprogramming of a key step in auxin signaling initiation that enhances viral infection and pathogenesis.
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