ArticlePLoS computational biology2016
The C. elegans Connectome Consists of Homogenous Circuits with Defined Functional Roles.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Phospholipase Cβ regulates negative associative memory through calcium dependent and independent mechanisms.The Journal of biological chemistry · 2026Article
- Bilateral Neuron Pairs Share Redundant Network Roles Despite Incomplete Connection Symmetry in Caenorhabditis elegans.The European journal of neuroscience · 2026Article
- Signed motif analysis of the Caenorhabditis elegans neuronal network reveals positive feedforward and negative feedback loops.BMC biology · 2026Article
- Article
- Homophily within and across groups.Nature communications · 2025Article
- Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.PloS one · 2024Article
- The synaptic organization in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Emergent dynamics in a robotic model based on theFrontiers in neurorobotics · 2022Article
- Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.Bioscience reports · 2021Review
- Article
- Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems inNeuromethods · 2021Article
- Deriving pairwise transfer entropy from network structure and motifs.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Developmental trajectory of Caenorhabditis elegans nervous system governs its structural organization.PLoS computational biology · 2020Article
- Novel Technological Advances in Functional Connectomics inJournal of developmental biology · 2019Review
- Hub connectivity, neuronal diversity, and gene expression in the Caenorhabditis elegans connectome.PLoS computational biology · 2018Article
- Evolutionary regime transitions in structured populations.PloS one · 2018Article
- Machine learning in postgenomic biology and personalized medicine.Wiley interdisciplinary reviews. Data mining and knowledge discoveryArticle
Corrections and comments
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A major goal of systems neuroscience is to decipher the structure-function relationship in neural networks. Here we study network functionality in light of the common-neighbor-rule (CNR) in which a pair of neurons is more likely to be connected the more common neighbors it shares. Focusing on the fully-mapped neural network of C. elegans worms, we establish that the CNR is an emerging property in this connectome. Moreover, sets of common neighbors form homogenous structures that appear in defined layers of the network. Simulations of signal propagation reveal their potential functional roles: signal amplification and short-term memory at the sensory/inter-neuron layer, and synchronized activity at the motoneuron layer supporting coordinated movement. A coarse-grained view of the neural network based on homogenous connected sets alone reveals a simple modular network architecture that is intuitive to understand. These findings provide a novel framework for analyzing larger, more complex, connectomes once these become available.
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