Evidence map›Paper›PMID 27606352›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2016

Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis.

Keren Regev, Anu Paul, Brian Healy, Felipe von Glenn, Camilo Diaz-Cruz, Taha Gholipour, Maria Antonietta Mazzola, Radhika Raheja, Parham Nejad, Bonnie I Glanz and 4 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Keren RegevAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Anu PaulAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Brian HealyAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Felipe von GlennAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Camilo Diaz-CruzAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Taha GholipourAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Maria Antonietta MazzolaAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Radhika RahejaAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Parham NejadAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Bonnie I GlanzAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Pia KivisakkAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Tanuja ChitnisAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Howard L WeinerAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Roopali GandhiAnn Romney Center for Neurologic Diseases (K.R., A.P., B.H., F.v.G., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), and Partners MS Center (C.D.-C., T.G., P.N., B.I.G., T.C., H.L.W.), Brigham & Women's Hospital, Harvard Medical School, Boston; and Biostatistics Center (B.H.), Massachusetts General Hospital, Boston.
Brigham and Women's Hospital · US

Funding

Evaluation of biofluid exRNA isolation by small RNAseqUH3TR000890 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI WEINER, HOWARD L · 2015 to 2017
$1.1M
NCATS NIH HHS UH3 TR000890
6 · The paper itself

Abstract

objectiveTo identify circulating microRNAs (miRNAs) linked to disease stage and disability in multiple sclerosis (MS).

methodsSera from 296 participants including patients with MS, other neurologic diseases (Alzheimer disease and amyotrophic lateral sclerosis), and inflammatory diseases (rheumatoid arthritis and asthma) and healthy controls (HCs) were tested. miRNA profiles were determined using LNA (locked nucleic acid)-based quantitative PCR. Patients with MS were categorized according to disease stage and disability. In the discovery phase, 652 miRNAs were measured in sera from 26 patients with MS and 20 HCs. Following this, significant miRNAs (p < 0.05) from the discovery set were validated using quantitative PCR in 58 patients with MS, 30 HCs, and in 74 samples from other disease controls (Alzheimer disease, amyotrophic lateral sclerosis, asthma, and rheumatoid arthritis).

resultsWe validated 7 miRNAs that differentiate patients with MS from HCs (p < 0.05 in both the discovery and validation phase); miR-320a upregulation was the most significantly changing serum miRNA in patients with MS. We also identified 2 miRNAs linked to disease progression, with miR-27a-3p being the most significant. Ten miRNAs correlated with the Expanded Disability Status Scale of which miR.199a.5p had the strongest correlation with disability. Of the 15 unique miRNAs we identified in the different group comparisons, 12 have previously been reported to be associated with MS but not in serum.

conclusionsOur findings identify circulating serum miRNAs as potential biomarkers to diagnose and monitor disease status in MS. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that circulating serum miRNAs can be used as biomarker for MS.

Identifiers

PMID27606352
PMCPMC4996540
OpenAlexW2511350458

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.