Evidence map›Paper›PMID 27606324›Full record

ArticleMolecular neuropsychiatry2016

The Planar Cell Polarity Transmembrane Protein Vangl2 Promotes Dendrite, Spine and Glutamatergic Synapse Formation in the Mammalian Forebrain.

Nathan D Okerlund, Robert E Stanley, Benjamin N R Cheyette

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neuropsychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
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  7. Review
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  10. Review
  11. Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nathan D OkerlundDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, Calif., USA; Department of Psychiatry, Stanford University, Palo Alto, Calif., USA.
Robert E StanleyDepartment of Psychiatry, Stanford University, Palo Alto, Calif., USA; Tetrad Graduate Program, Stanford University, Palo Alto, Calif., USA.
Benjamin N R CheyetteDepartment of Psychiatry, Stanford University, Palo Alto, Calif., USA; Tetrad Graduate Program, Stanford University, Palo Alto, Calif., USA; UCSF Weill Institute for Neurosciences, University of California, San Francisco (UCSF), San Francisco, Calif., USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco (UCSF), San Francisco, Calif., USA.
Stanford University · US

Funding

PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
The Dact/Sestd1 pathway in embryonic malformationsR01HD055300 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEYETTE, BENJAMIN N.R. · 2007 to 2017
$3.4M
NICHD NIH HHS R01 HD055300NICHD NIH HHS T32 HD007470
6 · The paper itself

Abstract

The transmembrane protein Vangl2, a key regulator of the Wnt/planar cell polarity (PCP) pathway, is involved in dendrite arbor elaboration, dendritic spine formation and glutamatergic synapse formation in mammalian central nervous system neurons. Cultured forebrain neurons from Vangl2 knockout mice have simpler dendrite arbors, fewer total spines, less mature spines and fewer glutamatergic synapse inputs on their dendrites than control neurons. Neurons from mice heterozygous for a semidominant Vangl2 mutation have similar but not identical phenotypes, and these phenotypes are also observed in Golgi-stained brain tissue from adult mutant mice. Given increasing evidence linking psychiatric pathophysiology to these subneuronal sites and structures, our findings underscore the relevance of core PCP proteins including Vangl2 to the underlying biology of major mental illnesses and their treatment.

Indexed as

DendriteForebrainPlanar cell polarityPyramidal neuronSpineSynapseVangl2Wnt

Identifiers

PMID27606324
PMCPMC4996007
OpenAlexW2473728453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.