ReviewMolecular neuropsychiatry2016
A Review of Genome-Wide Association Studies of Stimulant and Opioid Use Disorders.
Review in Molecular neuropsychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Biochemical Diagnosis in Substance and Non-substance Addiction.Advances in experimental medicine and biology · 2025Review
- Investigating the neurobiology of maternal opioid use disorder and prenatal opioid exposure using brain organoid technology.Frontiers in cellular neuroscience · 2024Review
- FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.Journal of personalized medicine · 2022Article
- A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity.Genes, brain, and behavior · 2021Article
- Addiction-Associated Genetic Variants Implicate Brain Cell Type- and Region-Specific Cis-Regulatory Elements in Addiction Neurobiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Spontaneously Hypertensive Rat substrains show differences in model traits for addiction risk and cocaine self-administration: Implications for a novel rat reduced complexity cross.Behavioural brain research · 2021Article
- Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.Psychopharmacology · 2021Article
- Understanding the genetics and neurobiological pathways behind addiction (Review).Experimental and therapeutic medicine · 2021Review
- Integration of evidence across human and model organism studies: A meeting report.Genes, brain, and behavior · 2021Review
- Generational Effects of Opioid Exposure.Encyclopedia · 2021Article
- Sex-dependent effects of an Hnrnph1 mutation on fentanyl addiction-relevant behaviors but not antinociception in mice.Genes, brain, and behavior · 2021Article
- 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders.Journal of molecular neuroscience : MN · 2020Article
- Opioid use disorder.Nature reviews. Disease primers · 2020Review
- A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interactionJournal of psychiatry & neuroscience : JPN · 2020Article
- Article
- Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.The European journal of neuroscience · 2019Review
- National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies.Genes, brain, and behavior · 2019Review
- Characterization of DSM-IV Opioid Dependence Among Individuals of European Ancestry.Journal of studies on alcohol and drugs · 2019Article
- Transcriptomic Characterization of the Human Insular Cortex and Claustrum.Frontiers in neuroanatomy · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substance use disorders (SUD) are a major contributor to disability and disease burden worldwide. Risk for developing SUDs is influenced by variation in the genome. Identifying the genetic variants that influence SUD risk may help us to understand the biological mechanisms for the disorders and improve treatments. Genome-wide association studies (GWAS) have been successful in identifying many regions of the genome associated with common human disorders. Here, findings from recent GWAS of SUDs that involve illicit substances will be reviewed. Several GWAS have been reported, including studies on opioid and stimulant use disorder (cocaine and methamphetamine). Several of these GWAS report associations that are biologically interesting and statistically robust. Replication of the associations in independent samples and functional studies to understand the basis for the statistical associations will be important next steps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.