Evidence map›Paper›PMID 27606315›Full record

ArticleMolecular neuropsychiatry2015

Altered Brain Structure-Function Relationships Underlie Executive Dysfunction in 22q11.2 Deletion Syndrome.

Rachel K Jonas, Maria Jalbrzikowski, Caroline A Montojo, Arati Patel, Leila Kushan, Carolyn C Chow, Therese Vesagas, Carrie E Bearden

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neuropsychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rachel K JonasSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Maria JalbrzikowskiSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Caroline A MontojoSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Arati PatelSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Leila KushanSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Carolyn C ChowSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Therese VesagasSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
Carrie E BeardenSemel Institute for Neuroscience and Human Behavior, University of California-Los Angeles, Los Angeles, Calif., USA.
University of California, Los Angeles · US

Funding

UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
Endophenotypes of Dopaminergic Dysregulation in 22q11.2 Deletion SyndromeF31MH102999 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONAS, RACHEL KAREN · 2014 to 2017
$93k
NICHD NIH HHS U54 HD087101NIMH NIH HHS F31 MH102999
6 · The paper itself

Abstract

22q11.2 deletion syndrome (22q11DS) is a neurogenetic disorder associated with elevated rates of developmental neuropsychiatric disorders and impaired executive function (EF). Disrupted brain structure-function relationships may underlie EF deficits in 22q11DS. We administered the Behavior Rating Inventory of Executive Function (BRIEF) to assess real-world EF in patients with 22q11DS and matched controls (n = 86; age 6-17 years), along with cognitive measures that tap behavioral regulation and metacognition aspects of EF. Using FreeSurfer's whole-brain vertex cortical thickness pipeline, we investigated brain structure-EF relationships in patients with 22q11DS and controls. Behaviorally, patients with 22q11DS were impaired on multiple EF measures. Right orbitofrontal cortical thickness showed a differential relationship between real-world EF in patients with 22q11DS and controls. We also observed a group difference in the relationship between behavioral regulation and metacognition measures with thickness of ventral and dorsolateral prefrontal regions, respectively. Our findings suggest that executive dysfunction characteristic of 22q11DS is underscored by altered prefrontal cortical structure.

Indexed as

Cognitive functionCopy number variationDopamineMagnetic resonance imagingNeurodevelopmentNeurogeneticsPrefrontal cortex

Identifiers

PMID27606315
PMCPMC4996003
OpenAlexW2271951602

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.