ArticleMolecular autism2016
Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families.
Article in Molecular autism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Associations among maternal prenatal depression, maternal autism traits, and child autism traits in the Environmental Influences on Child Health Outcome (ECHO) program.Journal of neurodevelopmental disorders · 2026Article
- Assortative Mating and Increase in Prevalence and Severity of Autistic Spectrum Disorder in Children-A Systematic Review.Children (Basel, Switzerland) · 2026Review
- An Examination of Family Transmission of Traits Measured by the Social Responsiveness Scale-Short Form.Journal of autism and developmental disorders · 2024Article
- Mate selection and current trends in the prevalence of autism.Molecular autism · 2024Article
- Can the "female protective effect" liability threshold model explain sex differences in autism spectrum disorder?Neuron · 2022Review
- Altered intrinsic brain activity and connectivity in unaffected parents of individuals with autism spectrum disorder: a resting-state fMRI study.Frontiers in human neuroscience · 2022Article
- Genetic counseling as preventive intervention: toward individual specification of transgenerational autism risk.Journal of neurodevelopmental disorders · 2021Article
- Father-Child Interactions in Preschool Children with ASD: A Systematic Review.Brain sciences · 2021Review
- Validation of Social Responsiveness Scale for Korean Preschool Children With Autism.Psychiatry investigation · 2021Article
- Distributional Properties and Criterion Validity of a Shortened Version of the Social Responsiveness Scale: Results from the ECHO Program and Implications for Social Communication Research.Journal of autism and developmental disorders · 2021Article
- Emotional Availability and Play in Mother-Child Dyads with ASD: Changes during a Parental Based Intervention.Brain sciences · 2020Article
- Cortical signatures in behaviorally clustered autistic traits subgroups: a population-based study.Translational psychiatry · 2020Article
- Behavioral predictors of autism recurrence are genetically independent and influence social reciprocity: evidence that polygenic ASD risk is mediated by separable elements of developmental liability.Translational psychiatry · 2019Article
- Mothers of children with autism spectrum disorders: Play behaviors with infant siblings and social responsiveness.Autism : the international journal of research and practice · 2019Article
- Early behavioral indices of inherited liability to autism.Pediatric research · 2019Review
- Broader autism phenotype in parents of children with autism: a systematic review of percentage estimates.Journal of child and family studies · 2018Article
- Deconstructing autism: from unitary syndrome to contributory developmental endophenotypes.International review of psychiatry (Abingdon, England) · 2018Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecent studies have indicated that quantitative autistic traits (QATs) of parents reflect inherited liabilities that may index background genetic risk for clinical autism spectrum disorder (ASD) in their offspring. Moreover, preferential mating for QATs has been observed as a potential factor in concentrating autistic liabilities in some families across generations. Heretofore, intergenerational studies of QATs have focused almost exclusively on Caucasian populations-the present study explored these phenomena in a well-characterized Hispanic population.
methodsThe present study examined QAT scores in siblings and parents of 83 Hispanic probands meeting research diagnostic criteria for ASD, and 64 non-ASD controls, using the Social Responsiveness Scale-2 (SRS-2). Ancestry of the probands was characterized by genotype, using information from 541,929 single nucleotide polymorphic markers.
resultsIn families of Hispanic children with an ASD diagnosis, the pattern of quantitative trait correlations observed between ASD-affected children and their first-degree relatives (ICCs on the order of 0.20), between unaffected first-degree relatives in ASD-affected families (sibling/mother ICC = 0.36; sibling/father ICC = 0.53), and between spouses (mother/father ICC = 0.48) were in keeping with the influence of transmitted background genetic risk and strong preferential mating for variation in quantitative autistic trait burden. Results from analysis of ancestry-informative genetic markers among probands in this sample were consistent with that from other Hispanic populations.
conclusionsQuantitative autistic traits represent measurable indices of inherited liability to ASD in Hispanic families. The accumulation of autistic traits occurs within generations, between spouses, and across generations, among Hispanic families affected by ASD. The occurrence of preferential mating for QATs-the magnitude of which may vary across cultures-constitutes a mechanism by which background genetic liability for ASD can accumulate in a given family in successive generations.
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