ArticleAfrican health sciences2016
Intestinal ameliorative effects of traditional Ogi-tutu, Vernonia amygdalina and Psidium guajava in mice infected with Vibrio cholera.
Article in African health sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ethnobotany, phytochemistry, and biological activities ofFrontiers in pharmacology · 2024Pooled it
- Ethnomedicinal Survey of Plants Used for Treatment of Mild COVID-19-Related Symptoms in Gorontalo Province, Indonesia.Scientifica · 2025Article
- Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria.Pathogens (Basel, Switzerland) · 2023Review
- Ethnobotany, Ethnopharmacology, and Phytochemistry of Medicinal Plants Used for Treating Human Diarrheal Cases in Rwanda: A Review.Antibiotics (Basel, Switzerland) · 2021Review
- A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective.Frontiers in pharmacology · 2020Review
- Antimicrobial Importance of Medicinal Plants in Nigeria.TheScientificWorldJournal · 2020Review
- Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade.International journal of molecular sciences · 2017Review
- From MNHC, NCDs to prevention of infectious diseases and plantibodies: meeting challenges of our times.African health sciences · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholera, a severe acute watery diarrhea caused by Vibrio cholerae is endemic in Nigeria with most cases occurring in the rural areas. In South West Nigeria, some individuals resort to alternative treatments such as Ogi-tutu, Psidium guajava and Vernonia amygdalina during infections. The effectiveness of these alternatives in the prevention and treatment of V. cholerae infection requires experimental investigation.
objectiveThis study was designed to investigate the ameliorative effects of Ogi-tutu, Vernonia amygdalina and Psidium guajava on intestinal histopathology of experimental mice infected with V. cholerae.
methodsPreliminary investigation of in vitro vibriocidal activities of these alternatives were carried out using agar cup diffusion assay. For ameliorative effects, adult mice were inoculated with 100 µl (106 cells) of Vibrio cholerae and dosed at 0 h (immediate prevention) and 4 h (treatment of infection) and their intestines were histopathologically evaluated.
resultsThe histopathological changes were the same irrespective of the treated groups, but the lesions varied in extent and severity. The ameliorative effects in decreasing order were V. amygdalina > P. guajava > Ogi-tutu.
conclusionV. amygdalina gave the best ameliorative effects in the prevention and treatment of V. cholerae infection.
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