Evidence map›Paper›PMID 27605943›Full record

ReviewJournal of geriatric cardiology : JGC2016

Sarcopenia in heart failure: mechanisms and therapeutic strategies.

Agnese Collamati, Emanuele Marzetti, Riccardo Calvani, Matteo Tosato, Emanuela D'Angelo, Alex N Sisto, Francesco Landi

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of geriatric cardiology : JGC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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  12. J-shaped relationship between serum creatinine and mortality in Korean patients with acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Agnese CollamatiCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
Emanuele MarzettiCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
Riccardo CalvaniCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
Matteo TosatoCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
Emanuela D'AngeloCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
Alex N SistoCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
Francesco LandiCenter for Geriatric Medicine (CEMI), Institute of Internal Medicine and Geriatrics Catholic, University of the Sacred Heart, Rome, Italy.
University of the Sacred Heart · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic heart failure (CHF) is a highly prevalent condition among the elderly and is associated with considerable morbidity, institutionalization and mortality. In its advanced stages, CHF is often accompanied by the loss of muscle mass and strength. Sarcopenia is a geriatric syndrome that has been actively studied in recent years due to its association with a wide range of adverse health outcomes. The goal of this review is to discuss the relationship between CHF and sarcopenia, with a focus on shared pathophysiological pathways and treatments. Malnutrition, systemic inflammation, endocrine imbalances, and oxidative stress appear to connect sarcopenia and CHF. At the muscular level, alterations of the ubiquitin proteasome system, myostatin signaling, and apoptosis have been described in both sarcopenia and CHF and could play a role in the loss of muscle mass and function. Possible therapeutic strategies to impede the progression of muscle wasting in CHF patients include protein and vitamin D supplementation, structured physical exercise, and the administration of angiotensin-converting enzyme inhibitors and β-blockers. Hormonal supplementation with growth hormone, testosterone, and ghrelin is also discussed as a potential treatment.

Indexed as

GhrelinMuscle lossProtein supplementationVitamin D

Identifiers

PMID27605943
PMCPMC4996837
OpenAlexW2520987032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.