Evidence map›Paper›PMID 27605923›Full record

ArticleFrontiers in neurology2016

Multi-Disciplinary Management of Athletes with Post-Concussion Syndrome: An Evolving Pathophysiological Approach.

Michael J Ellis, John Leddy, Barry Willer

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07527663 (Effectiveness of Sensorimotor Multi-axis Automated Rotational Therapy), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07527663 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Sensorimotor Multi-axis Automated Rotational Therapy (SMART) for Post-Concussion Syndrome Rehabilitation

TypeinterventionalSponsorNeuroscience GroupRan2026 to 2027Enrolled128ConditionsPost Concussion SyndromeArmsSensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Neuro-Visual and Vestibular Manifestations of Concussion and Mild TBI.Current neurology and neuroscience reports · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael J EllisPan Am Concussion Program, Section of Neurosurgery, Department of Surgery, Pediatrics and Child Health, University of Manitoba, Children's Hospital Research Institute of Manitoba, Canada North Concussion Network , Winnipeg, MB , Canada.
John LeddyUBMD Department of Orthopaedics and Sports Medicine, State University of New York at Buffalo Jacobs School of Medicine and Biomedical Sciences , Buffalo, NY , USA.
Barry WillerDepartment of Psychiatry, State University of New York at Buffalo Jacobs School of Medicine and Biomedical Sciences , Buffalo, NY , USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Historically, patients with sports-related concussion (SRC) have been managed in a uniform fashion consisting mostly of prescribed physical and cognitive rest with the expectation that all symptoms will spontaneously resolve with time. Although this approach will result in successful return to school and sports activities in the majority of athletes, an important proportion will develop persistent concussion symptoms characteristic of post-concussion syndrome (PCS). Recent advances in exercise science, neuroimaging, and clinical research suggest that the clinical manifestations of PCS are mediated by unique pathophysiological processes that can be identified by features of the clinical history and physical examination as well as the use of graded aerobic treadmill testing. Athletes who develop PCS represent a unique population whose care must be individualized and must incorporate a rehabilitative strategy that promotes enhanced recovery of concussion-related symptoms while preventing physical deconditioning. In this review, we present our evolving evidence-based approach to evaluation and management of athletes with PCS that aims to identify the pathophysiological mechanisms mediating persistent concussion symptoms and guides the initiation of individually tailored rehabilitation programs that target these processes. In addition, we outline the important qualified roles that multi-disciplinary healthcare professionals can play in the management of this patient population, and discuss where future research efforts must be focused to further evaluate this evolving pathophysiological approach.

Indexed as

athletemanagementmulti-disciplinarypost-concussion syndromesports-related concussiontreatment

Identifiers

PMID27605923
PMCPMC4995355

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.