ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2016
In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm.
Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- In vitro anthelmintic efficacy of Ferulic and Sinapic acid against zoonotic cestodeJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Gallic acid and Catechin induce morphological alterations on the zoonotic parasite Hymenolepis diminuta.Parasitology research · 2023Article
- β-Sitosterol Inhibits The Proliferation of Endometrial Cells via Regulating Smad7-Mediated TGF-β/Smads Signaling Pathway.Cell journal · 2023Article
- Therapeutic efficacy of β-sitosterol treatment onFrontiers in microbiology · 2023Article
- The therapeutic potential ofHeliyon · 2022Review
- Herbal anthelmintic agents: a narrative review.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Review
- In vitro and in vivo anthelmintic study ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes.Biomolecules · 2020Review
- Anthelmintic Activity of Extracts and Active Compounds FromFrontiers in veterinary science · 2020Article
- In vitro and in vivo anthelmintic efficacy of two pentacyclic triterpenoids, ursolic acid and betulinic acid against mice pinworm,Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- Efficacy of ursolic acid against Echinococcus granulosus in vitro and in a murine infection model.Parasites & vectors · 2018Article
- Therapecutic efficacy of the leaf extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Article
- Anticestodal properties ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Anthelmintic effects of Oroxylum indicum stem bark extract on juvenile and adult stages of Hymenolepis diminuta (Cestoda), an in vitro and in vivo study.Parasitology research · 2016Article
- β-sitosterol Mediated Silver Nanoparticles Induce Cytotoxicity in Human Colon Cancer HT-29 Cells.Avicenna journal of medical biotechnologyArticle
- Article
- Anthelmintic activity of a standardized extract from the rhizomes ofJournal of intercultural ethnopharmacologyArticle
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A large number of medicinal plants are used as herbal remedy for the treatment of helminthic diseases in the developing countries, however, far too little attention has been paid to assess the anthelmintic potentials of chemical compounds that are present in these plants. This study was carried out to assess the in vitro anthelmintic effects of biochanin A, ursolic acid, betulinic acid and beta-sitosterol which are the major phytochemicals of Trifolium repens, Houttuynia cordata and Lasia spinosa, the traditionally used anthelmintic plants of Northeast India. The in vitro anthelmintic testing of these phytochemicals was undertaken against Hymenolepis diminuta, a zoonotic tapeworm, and their efficacy was compared with a reference drug, praziquantel. The results revealed that except beta-sitosterol, which showed a very weak anthelmintic effect, remaining all other tested compounds possess highly significant (p ≤ 0.001) and dose-dependent anthelmintic effects. Upon exposure to 0.25, 0.50 and 1 mg/ml concentrations of biochanin A, ursolic acid and betulinic acid, the test parasite H. diminuta, at first, showed a paralyzed state which later culminated into their mortality after short time periods. Of all the phytochemicals tested, betulinic acid (1 mg/ml) showed the best anthelmintic effect and caused the mortality of test parasites at 3.4 ± 0.66 h. In conclusion, the results of this study demonstrate for the first time that betulinic acid, biochanin A and ursolic acid possess significant in vitro anthelmintic effects against H. diminuta, a zoonotic tapeworm, and, therefore, these compounds may be exploited further for anthelmintic drug development.
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