ArticleThe Journal of biological chemistry2016
The Mg2+-containing Water Cluster of Mammalian Cytochrome c Oxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- The three-dimensional structure of a proton-pumping pathway, the H-pathway, is evolutionarily conserved in all three families of cytochromeFrontiers in chemistry · 2025Article
- Moonlighting Proteins: Unveiling Their Multifunctionality in Metabolic Regulation and Drug Discovery.Current drug metabolism · 2025Review
- Structural and functional mechanisms of cytochrome c oxidase.Journal of inorganic biochemistry · 2025Review
- Heme-copper and Heme OJournal of inorganic biochemistry · 2023Review
- The biogenesis and regulation of the plant oxidative phosphorylation system.Plant physiology · 2023Review
- Recent progress in experimental studies on the catalytic mechanism of cytochromeFrontiers in chemistry · 2023Review
- Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.Nature communications · 2022Article
- Crystallographic studies of cytochrome c and cytochrome c oxidase.Journal of biochemistry · 2022Article
- Impact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics.International journal of molecular sciences · 2021Review
- Proton Pumping and Non-Pumping Terminal Respiratory Oxidases: Active Sites Intermediates of These Molecular Machines and Their Derivatives.International journal of molecular sciences · 2021Review
- Molecular understanding of heteronuclear active sites in heme-copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling.Chemical Society reviews · 2021Review
- Electron Transfer Coupled to Conformational Dynamics in Cell Respiration.Frontiers in molecular biosciences · 2021Article
- The 1.3-Å resolution structure of bovine cytochromeBBA advances · 2021Article
- Biochemical and crystallographic studies of monomeric and dimeric bovine cytochromeBiophysics and physicobiology · 2021Article
- Review
- An Unusual Amino Acid Substitution Within Hummingbird CytochromeG3 (Bethesda, Md.) · 2020Article
- The road to the structure of the mitochondrial respiratory chain supercomplex.Biochemical Society transactions · 2020Review
- A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- X-ray structures of catalytic intermediates of cytochromeThe Journal of biological chemistry · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine heart cytochrome c oxidase (CcO) pumps four proton equivalents per catalytic cycle through the H-pathway, a proton-conducting pathway, which includes a hydrogen bond network and a water channel operating in tandem. Protons are transferred by H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.