Evidence map›Paper›PMID 27605546›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016

Toll-like receptor 3-activated macrophages confer anti-HCV activity to hepatocytes through exosomes.

Yu Zhou, Xu Wang, Li Sun, Li Zhou, Tong-Cui Ma, Li Song, Jian-Guo Wu, Jie-Liang Li, Wen-Zhe Ho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  8. Extracellular Vesicles inInternational journal of molecular sciences · 2024
    Review
  9. Article
  10. Macrophage-derived extracellular vesicles fromFrontiers in immunology · 2024
    Article
  11. Review
  12. Review
  13. Exosome and virus infection.Frontiers in immunology · 2023
    Review
  14. Review
  15. Review
  16. Review
  17. Review
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  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yu ZhouDepartment of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA; and yu.zhou@temple.edu.
Xu Wang
Li SunThe State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Li ZhouThe State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Tong-Cui MaThe State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Li Song
Jian-Guo WuThe State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Jie-Liang LiThe State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Wen-Zhe HoDepartment of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA; and wenzheho@temple.edu.
Wuhan Institute of Virology · CNWuhan University · CNTemple University · US

Funding

Opioids, HIV/HCV and Host Cell Innate ImmunityR01DA022177 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI HO, WENZHE · 2007 to 2017
$2.9M
Methamphetamine, Innate Immunity and HIVR01DA041302 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI HO, WENZHE · 2016 to 2020
$1.8M
Exosome in Methamphetamine and HIV-associated NeurodegenerationR21DA040329 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, JIELIANG · 2015 to 2016
$427k
NIDA NIH HHS R01 DA022177NIDA NIH HHS R01 DA041302NIDA NIH HHS R21 DA040329
6 · The paper itself

Abstract

Exosomes are a class of cell-released small vesicles that mediate intercellular communication by delivering functional factors to recipient cells. During hepatitis C virus (HCV) infection, the interaction between liver resident macrophages and hepatocytes is a key component in liver innate immunity. In this study, we explored the role of exosomes in the delivery of innate anti-HCV factors to hepatocytes from macrophages. We showed that supernatant from TLR3-activated macrophage cultures could efficiently inhibit HCV replication in Huh7 cells. This macrophage-mediated anti-HCV activity was through exosomes because inhibiting exosomes could abrogate the action of macrophages. Further analyses demonstrated that TLR3-activated macrophages release exosomes that contain anti-HCV microRNA (miRNA)-29 family members. Inhibiting miRNA29 could restore HCV replication. These findings suggest a novel antiviral mechanism in liver innate immunity against HCV infection and provide insights to support further studies on developing exosome-based delivery system for disease treatment.-Zhou, Y., Wang, X., Sun, L., Zhou, L., Ma, T.-C., Song, L., Wu, J.-G., Li, J.-L., Ho, W.-Z. Toll-like receptor 3-activated macrophages confer anti-HCV activity to hepatocytes through exosomes.

Indexed as

Cell CommunicationCell Line, TumorExosomesHepacivirusHepatocytesHumansImmunity, InnateLiverMacrophagesToll-Like Receptor 3Virus ReplicationTLR3 protein, humanToll-Like Receptor 3exosomeshepatitis C virusmiRNA

Identifiers

PMID27605546
PMCPMC5102108
OpenAlexW2508981910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.