Evidence map›Paper›PMID 27605542›Full record

Observational studyJournal of the American Society of Nephrology : JASN2017

The Survival Benefit of "Fistula First, Catheter Last" in Hemodialysis Is Primarily Due to Patient Factors.

Robert S Brown, Bhanu K Patibandla, Alexander S Goldfarb-Rumyantzev

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Observational
  7. Preemptive Vascular Access Placement and Mortality Risk in Hemodialysis Patients: A Real-World Single-Center Study.Hemodialysis international. International Symposium on Home Hemodialysis · 2026
    Article
  8. Article
  9. More than a Last Resort: The Role of Tunneled Catheters in Hemodialysis.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Robert S BrownDivision of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; and rbrown@bidmc.harvard.edu.
Bhanu K PatibandlaDivision of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon.
Alexander S Goldfarb-RumyantzevDivision of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; and.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients needing hemodialysis are advised to have arteriovenous fistulas rather than catheters because of significantly lower mortality rates. However, disparities in fistula placement raise the possibility that patient factors have a role in this apparent mortality benefit. We derived a cohort of 115,425 patients on incident hemodialysis ≥67 years old from the US Renal Data System with linked Medicare claims to identify the first predialysis vascular access placed. We compared mortality outcomes in patients initiating hemodialysis with a fistula placed first, a catheter after a fistula placed first failed, or a catheter placed first (n=90,517; reference group). Of 21,436 patients with a fistula placed first, 9794 initiated hemodialysis with that fistula, and 8230 initiated dialysis with a catheter after failed fistula placement. The fistula group had the lowest mortality over 58 months (hazard ratio, 0.50; 95% confidence interval, 0.48 to 0.52; P<0.001), with mortality rates at 6, 12, and 24 months after initiation of 9%, 17%, and 31%, respectively, compared with 32%, 46%, and 62%, respectively, in the catheter group. However, the group initiating hemodialysis with a catheter after failed fistula placement also had significantly lower mortality rates than the catheter group had over 58 months (hazard ratio, 0.66; 95% confidence interval, 0.64 to 0.68; P<0.001), with mortality rates of 15%, 25%, and 42% at 6, 12, and 24 months, respectively. Thus, patient factors affecting fistula placement, even when patients are hemodialyzed with a catheter instead, may explain at least two thirds of the mortality benefit observed in patients with a fistula.

Indexed as

Arteriovenous Shunt, SurgicalCatheters, IndwellingRenal DialysisAgedAged, 80 and overFemaleHumansKidney Failure, ChronicMaleRetrospective StudiesSurvival RateTime Factorsaccessarteriovenous fistuladialysishemodialysis accessmortalitymortality risk

Identifiers

PMID27605542
PMCPMC5280011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.