Evidence map›Paper›PMID 27605451›Full record

ArticleAmerican journal of physiology. Cell physiology2016

sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling.

Huey Lin, Mia Angeli, Kwang Jin Chung, Chukwuemeka Ejimadu, Angelica Rivera Rosa, Techung Lee

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 91 citations in OpenAlex.

  1. SFRP2Molecular carcinogenesis · 2026
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Huey LinDepartment of Biochemistry and Department of Biomedical Engineering, University at Buffalo, Buffalo, New York.
Mia AngeliDepartment of Biochemistry and Department of Biomedical Engineering, University at Buffalo, Buffalo, New York.
Kwang Jin ChungDepartment of Biochemistry and Department of Biomedical Engineering, University at Buffalo, Buffalo, New York.
Chukwuemeka EjimaduDepartment of Biochemistry and Department of Biomedical Engineering, University at Buffalo, Buffalo, New York.
Angelica Rivera RosaDepartment of Biochemistry and Department of Biomedical Engineering, University at Buffalo, Buffalo, New York.
Techung LeeDepartment of Biochemistry and Department of Biomedical Engineering, University at Buffalo, Buffalo, New York chunglee@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secreted Frizzled-related protein 2 (sFRP2) plays a key role in chronic fibrosis after myocardial infarction and in heart failure. The aim of this study was to elucidate the mechanisms through which sFRP2 may regulate the growth and extracellular matrix (ECM) remodeling of adult mouse cardiac fibroblasts (CFs). We found that sFRP2 activates CFs in part through canonical Wnt/β-catenin signaling, as evidenced by increased expression of Axin2 and Wnt3a, but not Wnt5a, as well as accumulation of nuclear β-catenin. In response to sFRP2, CFs exhibited robust cell proliferation associated with increased glucose consumption and lactate production, a phenomenon termed "the Warburg effect" in oncology. The coupling between CF expansion and anaerobic glycolysis is marked by upregulation of glyceraldehyde-3-phosphate dehydrogenase and tissue-nonspecific alkaline phosphatase. In conjunction with these phenotypic changes, CFs accelerated ECM remodeling through upregulation of expression of the matrix metalloproteinase (MMP) 1 and MMP13 genes, two members of the collagenase subfamily, and enzyme activities of MMP2 and MMP9, two members of the gelatinase subfamily. Consistent with the induction of multiple MMPs possessing collagenolytic activities, the steady-state level of collagen type 1 in CF-spent medium was reduced by sFRP2. Analysis of non-CF cell types revealed that the multifaceted effects of sFRP2 on growth control, glucose metabolism, and ECM regulation are largely restricted to CFs and highly sensitive to Wnt signaling perturbation. The study provides a molecular framework on which the functional versatility and signaling complexity of sFRP2 in cardiac fibrosis may be better defined.

Indexed as

Animalsbeta CateninCell ProliferationCells, CulturedCollagenasesCollagen Type IEnergy MetabolismExtracellular MatrixFibroblastsFibrosisHeartMembrane ProteinsMetalloendopeptidasesMiceMice, Inbred C57BLMyocardial Infarctionbeta CateninCollagenasesCollagen Type IMembrane ProteinsMetalloendopeptidasesSecreted Frizzled-Related ProteinsSfrp2 protein, mouseWnt Proteinscardiac fibroblastextracellular matrixmatrix metalloproteinasesecreted Frizzled-related protein 2Wnt

Identifiers

PMID27605451
PMCPMC5130588
OpenAlexW2510356781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.