ArticleScientific reports2016
A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- The Efficacy of Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder: An Umbrella Review of Meta-Analyses.CNS spectrums · 2024Pooled it
- Cervical spinal cord stimulation exerts anti-epileptic effects in a rat model of epileptic seizure through the suppression of CCL2-mediated cascades.Scientific reports · 2024Article
- The role of stimulus periodicity on spinal cord stimulation-induced artificial sensations in rodents.Journal of neural engineering · 2024Article
- Power-to-Noise Optimization in the Design of Neural Recording Amplifier Based on Current Scaling, Source Degeneration Resistor, and Current Reuse.Biosensors · 2024Article
- Spike sorting in the presence of stimulation artifacts: a dynamical control systems approach.Journal of neural engineering · 2024Article
- An RF-Ultrasound Relay for Adaptive Wireless Powering Across Tissue Interfaces.IEEE journal of solid-state circuits · 2022Article
- Brain-machine-brain interfaces as the foundation for the next generation of neuroprostheses.National science review · 2022Article
- Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Review
- Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia.IEEE transactions on bio-medical engineering · 2021Article
- A New Viewpoint on the Etiopathogenesis of Depression: Insights From the Neurophysiology of Deep Brain Stimulation in Parkinson's Disease and Treatment-Resistant Depression.Frontiers in psychiatry · 2021Article
- Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing.Frontiers in neuroscience · 2021Review
- A Brain to Spine Interface for Transferring Artificial Sensory Information.Scientific reports · 2020Article
- A Programmable Multi-biomarker Neural Sensor for Closed-loop DBS.IEEE access : practical innovations, open solutions · 2018Article
- Cortical GABAergic Interneuron/Progenitor Transplantation as a Novel Therapy for Intractable Epilepsy.Frontiers in cellular neuroscience · 2018Review
- Electrical stimulus artifact cancellation and neural spike detection on large multi-electrode arrays.PLoS computational biology · 2017Article
- The Hypothesis of Connecting Two Spinal Cords as a Way of Sharing Information between Two Brains and Nervous Systems.Frontiers in psychology · 2017Article
- Comparative Performance of Linear Multielectrode Probes and Single-Tip Electrodes for Intracortical Microstimulation and Single-Neuron Recording in Macaque Monkey.Frontiers in systems neuroscience · 2017Article
- Generating artificial sensations with spinal cord stimulation in primates and rodents.Brain stimulationArticle
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.