Evidence map›Paper›PMID 27605339›Full record

ReviewMicroarrays (Basel, Switzerland)2012

Integrated Amplification Microarrays for Infectious Disease Diagnostics.

Darrell P Chandler, Lexi Bryant, Sara B Griesemer, Rui Gu, Christopher Knickerbocker, Alexander Kukhtin, Jennifer Parker, Cynthia Zimmerman, Kirsten St George, Christopher G Cooney

Abstract readReview
In one paragraph

Review in Microarrays (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Darrell P ChandlerAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. dchandler@akonni.com.
Lexi BryantAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. lbryant@akonni.com.
Sara B GriesemerLaboratory of Viral Diseases, Wadsworth Center, New York State Dept of Health, 120 New Scotland Avenue, Albany, NY 12208, USA. sbg03@health.state.ny.us.
Rui GuLaboratory of Viral Diseases, Wadsworth Center, New York State Dept of Health, 120 New Scotland Avenue, Albany, NY 12208, USA. rxg11@health.state.ny.us.
Christopher KnickerbockerAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. cknickerbocker@akonni.com.
Alexander KukhtinAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. akukhtin@akonni.com.
Jennifer ParkerAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. jparker@akonni.com.
Cynthia ZimmermanAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. czimmerman@akonni.com.
Kirsten St GeorgeLaboratory of Viral Diseases, Wadsworth Center, New York State Dept of Health, 120 New Scotland Avenue, Albany, NY 12208, USA. kxs16@health.state.ny.us.
Christopher G CooneyAkonni Biosystems, Inc., 400 Sagner Avenue, Suite 300, Frederick, MD 21701, USA. cooney@akonni.com.

Funding

Diagnostic MDR- and XDR-TB PCR TruArrayRC3AI089106 · NIAID · AKONNI BIOSYSTEMS, INC. · PI CHANDLER, DARRELL P · 2010 to 2010
$3.0M
Diagnostic Influenza RT-PCR ArrayR44AI072784 · NIAID · AKONNI BIOSYSTEMS, INC. · PI CHANDLER, DARRELL P · 2009 to 2011
$3.0M
Diagnostic array for aseptic encephalitisR44AI085650 · NIAID · AKONNI BIOSYSTEMS, INC. · PI CHANDLER, DARRELL P, COONEY, CHRISTOPHER GERARD · 2014 to 2016
$3.0M
TB Diagnostics at the Point of CareR43EB011274 · NIBIB · AKONNI BIOSYSTEMS, INC. · PI COONEY, CHRISTOPHER GERARD · 2010 to 2011
$424k
Diagnostic array for aseptic encephalitisR43AI085650 · NIAID · AKONNI BIOSYSTEMS, INC. · PI CHANDLER, DARRELL P · 2011 to 2011
$300k
TB Diagnostics at the Point of CareSB1EB011274 · NIBIB · AKONNI BIOSYSTEMS, INC. · PI COONEY, CHRISTOPHER GERARD · 2017 to 2017
$149k
NIAID NIH HHS R43 AI085650NIAID NIH HHS R44 AI072784NIAID NIH HHS R44 AI085650NIAID NIH HHS RC3 AI089106NIBIB NIH HHS R43 EB011274NIBIB NIH HHS SB1 EB011274
6 · The paper itself

Abstract

This overview describes microarray-based tests that combine solution-phase amplification chemistry and microarray hybridization within a single microfluidic chamber. The integrated biochemical approach improves microarray workflow for diagnostic applications by reducing the number of steps and minimizing the potential for sample or amplicon cross-contamination. Examples described herein illustrate a basic, integrated approach for DNA and RNA genomes, and a simple consumable architecture for incorporating wash steps while retaining an entirely closed system. It is anticipated that integrated microarray biochemistry will provide an opportunity to significantly reduce the complexity and cost of microarray consumables, equipment, and workflow, which in turn will enable a broader spectrum of users to exploit the intrinsic multiplexing power of microarrays for infectious disease diagnostics.

Indexed as

asymmetric PCRdiagnosticsgel element arraysintegrated microarraysmicrofluidicsmultiplexreverse transcriptaseRT-PCR

Identifiers

PMID27605339
PMCPMC5003434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.