Evidence map›Paper›PMID 27605220›Full record

ArticleInflammation2016

Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats.

Wu Jiang, Maoqiang Li, Fan He, Wangxiang Yao, Zhenyu Bian, Xuepeng Wang, Liulong Zhu

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

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  15. The Crosstalk between Nrf2 and Inflammasomes.International journal of molecular sciences · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wu JiangDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China.
Maoqiang LiDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China.
Fan HeDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China.
Wangxiang YaoDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China.
Zhenyu BianDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China.
Xuepeng WangDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China.
Liulong ZhuDepartment of Orthopedics, Hangzhou First People's Hospital,Nanjing Medical University, No. 261 Huansha Road, Shangcheng District, Hangzhou, 310006, China. drzhuliulong@sina.com.
Hangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. We aimed to investigate the therapeutic efficacy and molecular mechanisms of AA on SCI-induced ALI. One-hundred and fifty Sprague-Dawley rats were randomly assigned to five groups: sham, SCI, SCI + dexamethasone (Dex, 2 mg/kg), SCI + AA (30 mg/kg), and SCI + AA (75 mg/kg). The influences of AA on histologic changes, pulmonary edema, neutrophil infiltration and activation, proinflammatory cytokine production, oxidative stress, and Nrf2 and NLRP3 inflammasome protein expression were estimated. AA administration at the 30- and 75-mg/kg doses significantly attenuates lung wet-to-dry weight (W/D) ratio, pulmonary permeability index (PPI), and pulmonary histologic conditions. Furthermore, the protective effects of AA might be attributed to the reduction of neutrophil infiltration, myeloperoxidase (MPO), inflammatory cytokines, reactive oxygen species (ROS), malondialdehyde (MDA), and the increase of superoxide dismutase (SOD) and catalase (CAT). Moreover, AA markedly upregulated Nrf2 levels and downregulated NLRP3 inflammasome protein expression in lung tissues. AA exhibits a protective effect on SCI-induced ALI by alleviating the inflammatory response, by inhibiting NLRP3 inflammasome activation and oxidative stress with the upregulation of Nrf2 protein levels. The use of AA may be a potential efficient therapeutic strategy for the treatment of SCI-induced ALI.

Indexed as

Acute Lung InjuryAnimalsCytokinesGene Expression RegulationInflammasomesInflammationNeutrophil InfiltrationNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinPentacyclic TriterpenesRatsRats, Sprague-DawleyReactive Oxygen SpeciesSpinal Cord Injuriesasiatic acidCytokinesInflammasomesNfe2l2 protein, ratNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratPentacyclic TriterpenesReactive Oxygen Speciesacute lung injuryasiatic acidNLRP3 inflammasomeNrf2spinal cord injury

Identifiers

PMID27605220
OpenAlexW2515565607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.