SynthesisNeurology2016
Adiposity and ischemic and hemorrhagic stroke: Prospective study in women and meta-analysis.
Synthesis in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Association between early age body mass index and the risk of adulthood cardiovascular diseases: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Differences in risk factors for 3 types of stroke: UK prospective study and meta-analyses.Neurology · 2018Pooled it
- Predisposing Factors, Pathologies, and Precipitating Factors Causing Intracerebral Hemorrhage.Stroke · 2026Review
- Metabolic score for visceral fat: a novel tool for assessing stroke risk in middle-aged and elderly Chinese adults - evidence from the CHARLS cohort study.BMC neurology · 2026Article
- Sex difference in predictors of aneurysmal wall enhancement: a cross-sectional and prospective cohort study.Neuroradiology · 2026Article
- Article
- Association between dietary vitamin B1 intake and stroke risk in older patients: a retrospective cross-sectional study.BMC neurology · 2025Article
- Association of Paternal Diabetes With Hemorrhagic Stroke in Bangladeshi Women: The MAGPIE Study.Health science reports · 2025Article
- Modifiable Risk Factors for Stroke in Syria: A Nationwide Multi-centre Case-Control Study.Scientific reports · 2025Article
- Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization.PloS one · 2025Article
- Sex-specific association between body mass index and cerebral microbleed progression in adults aged 50-85 years.Frontiers in neurology · 2025Article
- Modifiable Risk Factors for Subarachnoid Hemorrhage: Narrative Review With an Emphasis on Common Controversies and Epidemiologic Pitfalls.Neurology · 2024Review
- The MARVIN Hypothesis: Linking Unhealthy Lifestyles to Intracranial Aneurysm Rupture Risk and Clinical Prognosis.Medicina (Kaunas, Lithuania) · 2024Article
- Intracranial Aneurysms and Cerebral Small Vessel Disease: Is There an Association between Large- and Small-Artery Diseases?Journal of clinical medicine · 2024Article
- Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited.International journal of epidemiology · 2024Article
- Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels.Frontiers in aging neuroscience · 2024Article
- Stroke in Women: A Review Focused on Epidemiology, Risk Factors, and Outcomes.Journal of stroke · 2023Review
- Women and stroke: disparities in clinical presentation, severity, and short- and long-term outcomes.Frontiers in neurology · 2023Article
- Impact of obesity on all-cause and cause-specific mortality among critically ill men and women: a cohort study on the eICU database.Frontiers in nutrition · 2023Article
- Adiposity, Body Fat Distribution, and Risk of Major Stroke Types Among Adults in the United Kingdom.JAMA network open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo compare associations of body mass index (BMI) with ischemic stroke and hemorrhagic stroke risk, and to review the worldwide evidence.
methodsWe recruited 1.3 million previously stroke-free UK women between 1996 and 2001 (mean age 57 years [SD 5]) and followed them by record linkage for hospital admissions and deaths. We used Cox regression to estimate adjusted relative risks for ischemic and hemorrhagic (intracerebral or subarachnoid hemorrhage) stroke in relation to BMI. We conducted a meta-analysis of published findings from prospective studies on these associations.
resultsDuring an average follow-up of 11.7 years, there were 20,549 first strokes, of which 9,993 were specified as ischemic and 5,852 as hemorrhagic. Increased BMI was associated with an increased risk of ischemic stroke (relative risk 1.21 per 5 kg/m
conclusionsIn UK women, higher BMI is associated with increased risk of ischemic stroke but decreased risk of hemorrhagic stroke. The totality of the available published evidence suggests that BMI-associated risks are greater for ischemic than for hemorrhagic stroke.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.