ArticleJournal of orthopaedic surgery and research2016
Combination of platelet-rich plasma and bone marrow mesenchymal stem cells enhances tendon-bone healing in a rabbit model of anterior cruciate ligament reconstruction.
Article in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- Effect of bone marrow aspiration concentrate and platelet-rich plasma combination in anterior cruciate ligament reconstruction: a randomized, prospective, double-blinded study.Journal of orthopaedic surgery and research · 2024Trial
- Multi-omics-guided targeting of the CD14-NF-κB axis with PGA1-loaded liposomes restores CD14Materials today. Bio · 2026Article
- Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review).International journal of molecular medicine · 2026Review
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Platelet-Rich Plasma (PRP)/stem-cell therapy for a partial torn ulnar collateral ligament in a professional football player: case report.The Journal of the Canadian Chiropractic Association · 2025Article
- Total Flavonoids ofBiology · 2025Article
- Artificial ligaments in anterior cruciate ligament reconstruction: Coating strategies for PET-based materials.Journal of orthopaedic translation · 2025Review
- Letter to the editor regarding "Promotion of bone-tendon healing after ACL reconstruction using scaffold-free constructs comprising ADSCs produced by a bio-3D printer in rabbit models".Journal of orthopaedic translation · 2025Article
- Promotion of bone-tendon healing after ACL reconstruction using scaffold-free constructs comprising ADSCs produced by a bio-3D printer in rabbit models.Journal of orthopaedic translation · 2025Article
- Engineered exosomes: a promising strategy for tendon-bone healing.Journal of advanced research · 2024Review
- Advances in the application of hydrogel-based scaffolds for tendon repair.Genes & diseases · 2024Review
- Human Trials on the Prevention of Tunnel Widening by the Emdogain in Anterior Cruciate Ligament Reconstruction.Cureus · 2023Article
- Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey.Scientific reports · 2023Article
- The hydroxyapatite modified 3D printed poly L-lactic acid porous screw in reconstruction of anterior cruciate ligament of rabbit knee joint: a histological and biomechanical study.BMC musculoskeletal disorders · 2023Article
- Strategies to promote tendon-bone healing after anterior cruciate ligament reconstruction: Present and future.Frontiers in bioengineering and biotechnology · 2023Review
- Strategies for promoting tendon-bone healing: Current status and prospects.Frontiers in bioengineering and biotechnology · 2023Review
- Arthroscopic Rotator Cuff Repair with a Fibrin Scaffold Containing Growth Factors and Autologous Progenitor Cells Derived From Humeral cBMA Improves Clinical Outcomes in High Risk Patients.Arthroscopy, sports medicine, and rehabilitation · 2022Article
- Clinical perspectives for repairing rotator cuff injuries with multi-tissue regenerative approaches.Journal of orthopaedic translation · 2022Review
- Cell therapy efficacy and safety in treating tendon disorders: a systemic review of clinical studies.Journal of experimental orthopaedics · 2022Review
- The Efficacy of Platelet-Rich Plasma for Ligament Injuries: A Systematic Review of Basic Science Literature With Protocol Quality Assessment.Orthopaedic journal of sports medicine · 2022Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to investigate the potency of platelet-rich plasma (PRP) combined with bone marrow mesenchymal stem cells (BMSCs) to promote tendon-bone healing in a rabbit model.
methodsIn the in vitro study, the effects of PRP on osteogenic induction of BMSCs were analysed. Later, PRP with or without BMSCs was used in the rabbit model of anterior cruciate ligament reconstruction. Specimens were harvested 8 weeks postoperatively to evaluate tendon-bone healing by histology, radiology, and biomechanical testing.
resultsThe in vitro study revealed that collagen I, osteocalcin, and osteopontin expression was higher in BMSCs co-cultured with PRP for 14 days. The in vivo study revealed a more mature tendon-bone interface using light microscopy, a more newly formed bone at the bone tunnel walls detected by micro-computed tomography, and a significantly higher failure load as assessed by biomechanical testing in the BMSC + PRP group than in the control and PRP groups.
conclusionsThese results indicate that the combination of PRP and BMSCs promotes tendon-bone healing and has potential for clinical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.