ArticleNucleic acids research2017
Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Characterization of RNA interference in the cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification.PLoS biology · 2026Article
- microRNAs in Type 1 Diabetes: Roles, Pathological Mechanisms, and Therapeutic Potential.International journal of molecular sciences · 2025Review
- MicroRNAs: Small but Key Players in Viral Infections and Immune Responses to Viral Pathogens.Biology · 2023Review
- Massively parallel identification of mRNA localization elements in primary cortical neurons.Nature neuroscience · 2023Article
- Small RNAs in Cnidaria: A review.Evolutionary applications · 2023Article
- Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis.BMC biology · 2022Article
- The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.RNA (New York, N.Y.) · 2022Article
- Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response.Nucleic acids research · 2021Article
- Conservation and turnover of miRNAs and their highly complementary targets in early branching animals.Proceedings. Biological sciences · 2021Article
- MicroRNAs: From Mechanism to Organism.Frontiers in cell and developmental biology · 2020Review
- Small RNAs in eucaryotes: new clues for amplifying microRNA benefits.Cell & bioscience · 2020Review
- Mechanistic Insights into MicroRNA-Mediated Gene Silencing.Cold Spring Harbor perspectives in biology · 2019Review
- Determining Immune and miRNA Biomarkers Related to Respiratory Syncytial Virus (RSV) Vaccine Types.Frontiers in immunology · 2019Article
- Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease.Non-coding RNA · 2018Review
- Diverse RNA interference strategies in early-branching metazoans.BMC evolutionary biology · 2018Article
- Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes.Nature communications · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Our current knowledge about the mechanisms of miRNA silencing is restricted to few lineages such as vertebrates, arthropods, nematodes and land plants. miRNA-mediated silencing in bilaterian animals is dependent on the proteins of the GW182 family. Here, we dissect the function of GW182 protein in the cnidarian Nematostella, separated by 600 million years from other Metazoa. Using cultured human cells, we show that Nematostella GW182 recruits the CCR4-NOT deadenylation complexes via its tryptophan-containing motifs, thereby inhibiting translation and promoting mRNA decay. Further, similarly to bilaterians, GW182 in Nematostella is recruited to the miRNA repression complex via interaction with Argonaute proteins, and functions downstream to repress mRNA. Thus, our work suggests that this mechanism of miRNA-mediated silencing was already active in the last common ancestor of Cnidaria and Bilateria.
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